Mouse Anti-D. melanogaster Atxn7 Antibody (CBMOAB-02085FYA)


Cat: CBMOAB-02085FYA
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityFruit fly (Drosophila melanogaster)
CloneMO02085FYA
SpecificityThis antibody binds to fruit fly Atxn7.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationNucleus; Other locations

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThe autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 37-306 CAG repeats (near the N-terminus), compared to 4-35 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants.
Product OverviewMouse Anti-D. melanogaster Atxn7 Antibody is a mouse antibody against Atxn7. It can be used for Atxn7 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesAtaxin 7, isoform A; Ataxin 7, isoform B; Ataxin 7, isoform C; Ataxin 7, isoform D; LD40170p; Atxn7
UniProt IDQ9VQB6
Protein RefseqThe length of the protein is 971 amino acids long.
The sequence is show below: MPLNDVAPAGGGAYPENGTKHKVSGMWKPDSSAGSNSGSGSAGLSLFSLQGQKWQQVFDMEKVIKQLRTAEKTYLRGGKNSSAGADQQAKVQVQRLQSADMAYYDLAPKLASRDIVLCSSCSGCYTKAGFQHHIALQHPSVWEATSSKVNPNPNGTAISSDSRLTATEISQEGGAIVPSSPTDTLSASTLSSCSNGSSSSASLQHPAAAGSSSTTSSSSSSRHKSSSSKSSSSSSSKGSSSTSAGSRSRSKSSKNRHHSSPAPALLESNHKESKGSKKSSAIAAPPVVAAVVKEEPPSVGAAPAAITMFSSSSNSSCSLPPTPTLGAASSEVAMGVNYSPAQLQTDAEKLPELQPKKKLKGSSDHRIKAEKEKNKDKSLVNSYEQQQVLSELDQAVSSITGAVSAEQVAPDEEELPLPNTSDENSISQTLDEMLDSKLINEILNNFDESALDTSQQQSQQQAQNGSLSHPAQATKRLRFEDGTIGEDYAVYQQQAVQQVYGEEEHQQELTTIDAMQLQQLIYQQQQMLEQQQLQEQQQQQQQDQKLQDHEQQRQFSVYNVPSLTDEAMVNPQQQQLEEHMILPSIIYEITESNPVSMLEQKVLAEFLTNAGYENVDVNVVQSGGIQTNLSSGTEANQLADELADFEFSKLETVSDTVKTVKLEAKAASQPPTTNPQINHHPSLANAKYHEDSYFNVMLYSGAPRPLAMNTFGMVKLPQGLGVTFRKNLLTTRKANNNLLSLSGGNHLGVVGQLARTPPPPSPALSNGLPGKNPASGRTIYAQRSNVIAQDRLRCNKRALVGGKAGGGSSGSPGVMTAKRLNELLMGKAKKEEKPPPDSEDGGEQPTKDKERDKEEDNKLTFSFYEKRRRLLAGKLEQLQPLGRPSFTLPLQSNHNASQSQSHSPQQLLKKQLLRTLSDSSSNMNISNMNNISNLNSSNTPSANSNPPWKGNSSNPGGNSTPTSSDLMRVFV.
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For Research Use Only | Not For Clinical Use.
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