Mouse Anti-D. melanogaster Incenp Antibody (CBMOAB-21034FYA)


Cat: CBMOAB-21034FYA
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityFruit fly (Drosophila melanogaster)
CloneMO21034FYA
SpecificityThis antibody binds to fruit fly Incenp.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationCytoskeleton; Other locations

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionIn mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).
Product OverviewMouse Anti-D. melanogaster Incenp Antibody is a mouse antibody against Incenp. It can be used for Incenp detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesRE52507p; Fragment; Incenp
UniProt IDQ8IGP7
Protein RefseqThe length of the protein is 781 amino acids long.
The sequence is show below: LPPFEKNDKIEGTESGFAVCQIQSLDMEDILGVLGSLSDLRRELEVLRKAHFEELDHLFYGTGQPEAEAKPRDSAPAAKSQENSSVTPQQTKKRPKRLTSLAEDQNEPEAPDATANNTSARQSTRVSNSQLLAIAEDEHNSTASLMPPPPVPVSADTTLGSGRPQRAAKLKTEKLLKEPSLNRKMRRPSSEELVKVKVESEQRVSQFNSFTSAQALEENKLAEPELEEPAAETAEQQKPPEEASVTEDVNTTKTLRVKVKREKLSTEAVPPLTNAVSTANVTTVSSVTTEAARPDDTVASNTTTSTEVSKKVRKKKKDVESHRPIKVERFSDLDKSSPVSSRTRKCSSDSRTVQERSIYKDALEDPPVAEQSVAAVAPAAVNETVAISNATLVLGPAPTSDSPIGPAGDATFEVHSNDKKQPLSKQDSLLTEDESVEEKLPTTKLLSSIKAIKLPTRTHELFNPLLQSPVKMRVEAFENAANAQNSMRPKRGKDLQGTPGSNNTPKIGKLPAPTVGRFFTPTQTTSTLPLSSAQPKKGPASASKATSLLKTATGTNLRSVNSTSTKTLSRENSGDDFRKGLHNLAEERKKLREQKHQQAAQQREAKERERAERMAKLAAERAKKQEERKRIEERKRQELEELQRKMRQQEEAEALKKAKFKELEQQKLQQLTGAKPKKMLPPPPKTKYTWEMLHEDDSTDDEGKVTHKRPPAPTWSRSHVRGEAIAMQSHCPTDIIDSFFSVAPTTPDLKQIFPNIDPSQLKRNSSVLWSTPPRYSELPKY.
For Research Use Only | Not For Clinical Use.
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