Mouse Anti-MET Antibody (MO-AB-27268R)


Cat: MO-AB-27268R
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Lot Number

  • Product List
  • Specifications
  • Application Information
  • Target
Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
MO-AB-27268R Monoclonal Pig (Sus scrofa), A. aegpti (Aedes aegpti), Cat (Felis catus), Cattle (Bos taurus), Chicken (Gallus gallus), Dog (Canis lupus familiaris), Ferret (Mustela Putorius Furo), Frog (Xenopus laevis), Guinea pig (Cavia porcellus), Horse (Equus caballus), Marmoset, O. anatinus (Ornithorhynchus anatinus), Silkworm (Bombyx mori), Soybean (Glycine max), Zebrafish (Danio rerio) WB, ELISA MO27268R 100 µg
CBMOAB-86574FYA Monoclonal Zebrafish (Danio rerio) WB, ELISA MO86574FYA 100 µg
MO-AB-08596W Monoclonal Cat (Felis catus) WB, ELISA MO08596W 100 µg
MO-AB-31758W Monoclonal Dog (Canis lupus familiaris) WB, ELISA MO31758W 100 µg
MO-AB-35120W Monoclonal Ferret (Mustela Putorius Furo) WB, ELISA MO35120W 100 µg
MO-AB-42076W Monoclonal Guinea pig (Cavia porcellus) WB, ELISA MO42076W 100 µg
MO-AB-45489W Monoclonal Horse (Equus caballus) WB, ELISA MO45489W 100 µg
MO-AB-58990W Monoclonal Marmoset WB, ELISA MO58990W 100 µg
MO-AB-70045W Monoclonal Silkworm (Bombyx mori) WB, ELISA MO70045W 100 µg
MO-AB-15567R Monoclonal Cattle (Bos taurus) WB, ELISA MO15567R 100 µg
MO-AB-05123H Monoclonal Frog (Xenopus laevis) WB, ELISA MO05123C 100 µg
MO-AB-31882H Monoclonal Soybean (Glycine max) WB, ELISA MO31882C 100 µg
MO-AB-02892Y Monoclonal Chicken (Gallus gallus) WB, ELISA MO02892Y 100 µg
MO-AB-06075Y Monoclonal A. aegpti (Aedes aegpti) WB, ELISA MO06075Y 100 µg
MO-AB-06639Y Monoclonal O. anatinus (Ornithorhynchus anatinus) WB, ELISA MO06639Y 100 µg
MO-DKB-00123W Polyclonal Zebrafish (Danio rerio) ELISA, WB 100 µg

Specifications

Host speciesMouse (Mus musculus)
Species ReactivityPig (Sus scrofa), A. aegpti (Aedes aegpti), Cat (Felis catus), Cattle (Bos taurus), Chicken (Gallus gallus), Dog (Canis lupus familiaris), Ferret (Mustela Putorius Furo), Frog (Xenopus laevis), Guinea pig (Cavia porcellus), Horse (Equus caballus), Marmoset, O. anatinus (Ornithorhynchus anatinus), Silkworm (Bombyx mori), Soybean (Glycine max), Zebrafish (Danio rerio)
CloneMO27268R
SpecificityThis antibody binds to Pig MET.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionReceptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
Product OverviewThis product is a mouse antibody against MET. It can be used for MET detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesHepatocyte growth factor receptor; MET
UniProt IDK7GPY4
Protein RefseqThe length of the protein is 788 amino acids long.
The sequence is show below: MKAPAVLAPGILVLLFTLVQKSKGECKEALVKSTMNLNMQYQLPNFTAETPIQNVVLHKHHIYLGALNYIYVLNDIDLRKVAEYKTGPVLEHPDCFPCQDCSHKANLSGGIWRDNINMALLVDTYYDDQLISCGSVHRGTCQRHVLPPDNIADIKSEVHCMYSPQVDEEPSQCPDCVVSALGTKVLLSEKDRFINFFVGNTINSSYLPDHSLHSISVRRLKETQDGFKFLTDQSYIDVLPEFRDSYPIKYVHAFESNHFIYFLTVQRETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGTQLAKQIGANLNDDILYGVFAQSKPDSAEPMNRSAVCAFPVKYVNEFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEVRSDEYRTEFTTALQRIDLFMGQFNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRPGLSTPHVNFHLDSHPVSPEVIVEPLNQNGYTLVVTGKKITKIPLNGLGCEHFQSCSQCLSAPPFVQCGWCQDKCVQLEECPSGTWTQEICLPTVYKVFPTSAPLEGGTTLTICGWDFGFRRNNKFDLRKTKVLLGNESCTLTLSESTTNTLKCTVGPAMNEHFNMSIVISNGRGTTQYRTFSYVDPVITNISPSFGPKTGGTLLTLTGMHLNSGNSRHISIGGKTCTLKSVSDSILECYTPAQTTPTEFPIKLKIDLANREINSFTYREDPIVYEIHPTKSFISGGSTITGVGRNLNSVSVLRMVINVHEAERNFTV.
For Research Use Only | Not For Clinical Use.
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