Name: Mouse Anti-TOR2 Antibody (CBMOAB-04552CR)
SKU: CBMOAB-04552CR
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Sub Cat	Clonality	Species Reactivity	Application	Clone	Conjugate	Size
CBMOAB-04552CR	Monoclonal	Yeast, C. elegans (Caenorhabditis elegans), Silkworm (Bombyx mori)	WB, ELISA	MO04552CR		100 µg	Inquiry
Protein Refseq: The length of the protein is 2474 amino acids long. The sequence is show below: MNKYINKYTTPPNLLSLRQRAEGKHRTRKKLTHKSHSHDDEMSTTSNTDSNHNGPNDSGRVITGSAGHIGKISFVDSELDTTFSTLNLIFDKLKSDVPQERASGANELSTTLTSLAREVSAEQFQRFSNSLNNKIFELIHGFTSSEKIGGILAVDTLISFYLSTEELPNQTSRLANYLRVLIPSSDIEVMRLAANTLGRLTVPGGTLTSDFVEFEVRTCIDWLTLTADNNSSSSKLEYRRHAALLIIKALADNSPYLLYPYVNSILDNIWVPLRDAKLIIRLDAAVALGKCLTIIQDRDPALGKQWFQRLFQGCTHGLSLNTNDSVHATLLVFRELLSLKAPYLRDKYDDIYKSTMKYKEYKFDVIRREVYAILPLLAAFDPAIFTKKYLDRIMVHYLRYLKNIDMNAANNSDKPFILVSIGDIAFEVGSSISPYMTLILDNIREGLRTKFKVRKQFEKDLFYCIGKLACALGPAFAKHLNKDLLNLMLNCPMSDHMQETLMILNEKIPSLESTVNSRILNLLSISLSGEKFIQSNQYDFNNQFSIEKARKSRNQSFMKKTGESNDDITDAQILIQCFKMLQLIHHQYSLTEFVRLITISYIEHEDSSVRKLAALTSCDLFIKDDICKQTSVHALHSVSEVLSKLLMIAITDPVAEIRLEILQHLGSNFDPQLAQPDNLRLLFMALNDEIFGIQLEAIKIIGRLSSVNPAYVVPSLRKTLLELLTQLKFSNMPKKKEESATLLCTLINSSDEVAKPYIDPILDVILPKCQDASSAVASTALKVLGELSVVGGKEMTRYLKELMPLIINTFQDQSNSFKRDAALTTLGQLAASSGYVVGPLLDYPELLGILINILKTENNPHIRRGTVRLIGILGALDPYKHREIEVTSNSKSSVEQNAPSIDIALLMQGVSPSNDEYYPTVVIHNLMKILNDPSLSIHHTAAIQAIMHIFQNLGLRCVSFLDQIIPGIILVMRSCPPSQLDFYFQQLGSLISIVKQHIRPHVEKIYGVIREFFPIIKLQITIISVIESISKALEGEFKRFVPETLTFFLDILENDQSNKRIVPIRILKSLVTFGPNLEDYSHLIMPIVVRMTEYSAGSLKKISIITLGRLAKNINLSEMSSRIVQALVRILNNGDRELTKATMNTLSLLLLQLGTDFVVFVPVINKALLRNRIQHSVYDQLVNKLLNNECLPTNIIFDKENEVPERKNYEDEMQVTKLPVNQNILKNAWYCSQQKTKEDWQEWIRRLSIQLLKESPSACLRSCSSLVSVYYPLARELFNASFSSCWVELQTSYQEDLIQALCKALSSSENPPEIYQMLLNLVEFMEHDDKPLPIPIHTLGKYAQKCHAFAKALHYKEVEFLEEPKNSTIEALISINNQLHQTDSAIGILKHAQQHNELQLKETWYEKLQRWEDALAAYNEKEAAGEDSVEVMMGKLRSLYALGEWEELSKLASEKWGTAKPEVKKAMAPLAAGAAWGLEQWDEIAQYTSVMKSQSPDKEFYDAILCLHRNNFKKAEVHIFNARDLLVTELSALVNESYNRAYNVVVRAQIIAELEEIIKYKKLPQNSDKRLTMRETWNTRLLGCQKNIDVWQRILRVRSLVIKPKEDAQVRIKFANLCRKSGRMALAKKVLNTLLEETDDPDHPNTAKASPPVVYAQLKYLWATGLQDEALKQLINFTSRMAHDLGLDPNNMIAQSVPQQSKRVPRHVEDYTKLLARCFLKQGEWRVCLQPKWRLSNPDSILGSYLLATHFDNTWYKAWHNWALANFEVISMLTSVSKKKQEGSDASSVTDINEFDNGMIGVNTFDAKEVHYSSNLIHRHVIPAIKGFFHSISLSESSSLQDALRLLTLWFTFGGIPEATQAMHEGFNLIQIGTWLEVLPQLISRIHQPNQIVSRSLLSLLSDLGKAHPQALVYPLMVAIKSESLSRQKAALSIIEKMRIHSPVLVDQAELVSHELIRMAVLWHEQWYEGLDDASRQFFGEHNTEKMFAALEPLYEMLKRGPETLREISFQNSFGRDLNDAYEWLMNYKKSKDVSNLNQAWDIYYNVFRKIGKQLPQLQTLELQHVSPKLLSAHDLELAVPGTRASGGKPIVKISKFEPVFSVISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLQNDAECFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHREAKKIPLNIEHWVMLQMAPDYDNLTLLQKVEVFTYALNNTEGQDLYKVLWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKFPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMKVLRDNKGSLMAILEAFAFDPLINWGFDLPTKKIEEETGIQLPVMNANELLSNGAITEEEVQRVENEHKNAIRNARAMLVLKRITDKLTGNDIRRFNDLDVPEQVDKLIQQATSVENLCQHYIGWCPFW.
CBMOAB-12267HCB	Monoclonal	C. elegans (Caenorhabditis elegans)	WB, ELISA	MO12267HB		100 µg	Inquiry
Protein Refseq: The length of the protein is 310 amino acids long. The sequence is show below: MFLKCLFYTCCGETDIFNYHALYKDFDNKIFGQHLMAESVVHSIKSHWHNEHSQKPLVLSFHGGTGTGKNYVTEIIVNNTYRSGMHSPFVNYFVATNNFPNKKYIEDYKLELKDQLIRSARRCQRSIFIFDETDKLQSELIQVIKPFLDYYPAVFGVDFRKTIFIFLSNKGSKEIANIALEHHENGKIRSQLELKHFERTLMLSAFNEEGGLRNTDMISNQLIDHFIPFLPLSKFYVSQCIQVHLRKRGRHDLAKDGEFMQRVLDSLEFFPESSKIFSSSGCKRVNAKTDLEISKMGFSLNSKKEFNDEL.
MO-AB-70492W	Monoclonal	Silkworm (Bombyx mori)	WB, ELISA	MO70492W		100 µg	Inquiry
Protein Refseq: The length of the protein is 2424 amino acids long. The sequence is show below: MSNQVAQFVSGLKSRTVDIQIKTARELYHYAKTELREVPQEELTQFLDELNHQIFEMVSSNDVHEKKGGVLAIVCLIGGDCDTTKTRITRFANYLRNLLPSSDVGVMELAAKTVGRLATVSGIKRAEYVEFEVKRAFEWLSEERNEGRRHSAVLLLKELAIAMPTYFYQQVSGFFDHILIALKDPKQQIREAAAKALRAGLVVTSQRETAKQSTAKLQWYMQCYEEAMFSFEDIPLKEKSMTKEDRVHGGLLILNELLRCSNSVWEKKYTQFIHNFDTQKDLTVSDDIIFISAKLHSPSVKRGYLCDGFKTENVQYPVPIYESAVCRKLLTEKFEKICQDVMAQRVLKIQGIPQILLIIIPRLAAFNKEFFLKKYFSTTMHYLITCLRSREKDKNVAFTTIGLMAAALENDIKNYIPRIMEVIKQALPVRDTLTKKRIWVDPSIFACITLLAGTVKDLVVNDIKELLDPMFATGLSPSLTICLRELSLSLPNLRREISEGLLNMLSIVLRNKPFLHPGVPHSLEQQMSNMSLVIEVQDSASVVLALRTLGTFHFEGQHSLLMFVRRCAEHFLLSDQQEIRLEAVKTSAKLLADATLRTVNSPSRTLTLLTAEVIGKLLIVAVTDPDYEVRYWVLESLTDIFDIHLAQVENLTILFMAMNDEHLSIRELAICTVGRLSAVDPAYVMPGLRKVLIQFLTELEHSGMSRNKEQAARMLDNLILHAPKLVEPYMETILNVLVPKLKGSDSNPGVVISVLKAIGDLADVRGDNTGLKKWLPELLSILLELLSDASATEKRSVALWAFGQLISATGHVVTPYTEYPNLMDVLLNFLKTEQQPKDRRETIRVLGLLGALDPYKHKMTKGMKVDSTLVPVTDSKSEGNNFDMTTSEMLVNMSSPVLDEYYPAIVISTLMRILRDPTLQQHHTNVVQAVTFIFQSLGIKCVPYISRVTPSLLYVARATDNNNFREFLFTQLARLIAIVKQHIRNYLDKIFDLIKEFWTPNSFLQPTLILLVEYIAIALGSEFKVYLPQLMPQILRVLAHDTSKDRVVTEKLLYALQKFEDNLDDYMHLVIPSIVKLFDASDCPIHVAKVAMETVDILSDSLSYNELVSRIIHPLVRSLDSCAPLRQTAMDTLCALIVQLGRKYTDFIPLVQKVVVKHKIQHQNYELLLSRLQSSQTLAMHEFLQSTRRRPRNNNQEARIIVCDTSQSIRKLCVNAHSLKLAWTVSSRVSKDDWLEWLRRFSIGLLTESHSPALRACLDLAHNYSQLLRDLFNAAFVSCWTELDDTSRTELSNALEQALTAPDAPELAHTVLNLAEFMEHCEGGALPISTQLLGERAMHCRAYAKALHYKEEEFRNGATSQVVEALIHINNKLQQKEAAEGLLERVMAQREAGDTNLKVQIRWYEKLHNWEKALNLYSEKLSADPDDVDAYLGELRCYEALGEWLKLYNTVSESWVKMGTDEKYKAARLAAAAAWGLNEWDSMAKYVNFLPENTQDGAFYRAVLNIHNGEYKVSKQFIDLARTLLDSELTAVAGESYQRAYGALVNAQLLAELEEVITYKLVNERRETIRQAWWTRLQGGQRLVEDWRRILQVRSLVLTPQEDMATWLKFASLCRKSGAPRQAHKTLVMLLGTDPSKNRDMPLPTHEPRLTLAYAKHLWVAGDKQLAYDQLQRYIIGTETGDADHCRLLARCHLKLGSWCESLLGINEHSIPEILRNYAAATELSSDWYKAWHAWAYMNFETVLFYKHQDTNSGRTLSGERKMSPECIQQHTVPAVEGFFKSIYLSHGSSLQDTLRLLTLWFDYGHYPAVHEALVEGIRTIEINVWLQVIPQLIARIDTPRPLVGKLIHSLLIDIGKSHPQALVYPLTVASKSSFVARKNAANHILKSMCTHSSNLVNQAAMISEELIRVAILWHEQWYEALEEASRLYFSENDVNAMLKTLEPLHAMLERGPETVKEASFSHAYSRELNEAQDWCNRYKESGQVRDLNQAWDLYYHVFRRISRQLPQLTSLELQYVSPRLLNCRDLELAVPGSYVPDQDLIRIAHIQSSLQVISSKQRPRRLCIRGSNGKDYMFLLKGHEDLRQDERVMQLFGLVNTLLQADPDTFRRDLAIQRYAVIPLSTNSGLIGWVPHCDTLHFLIKDYRDKRKCLLNIEHRIMQRMASDLDKLMLMQKVEVFEHALEHTVGDDLAKLLWLKSPSSEVWFERRTNYTRSLAVMSMVGYILGLGDRHPSNIMLDRVTGKFLHIDFGDCFEVAVTRDKFPEKIPFRLTRMLINAMEVTGIEGTYRRTCESVMEVLHRHKDSVMAVLEAFVYDPLLNWRLIEATRRSRADPDACPAEPASPPRDLPRDPPREPPRDPAQPAEANLNKRALSIVNRVRDKLTGRDFPHIDETVSVQKQVDLLIQQATSNENLCQCYVGWCPFW.

Specifications

Host species	Mouse (Mus musculus)
Species Reactivity	Yeast, C. elegans (Caenorhabditis elegans), Silkworm (Bombyx mori)
Clone	MO04552CR
Specificity	This antibody binds to Yeast TOR2.
Format	Liquid or Lyophilized
Storage	Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use
Purity	> 90% was determined by SDS-PAGE
Purification	Purified with Protein A or G affinity chromatography
Cellular Localization	Nucleus; Vacuole; Plasma Membrane; Other locations; Mitochondrion

Application Information

Application	WB, ELISA
Application Notes	ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

Introduction	Phosphatidylinositol 3-kinase homolog, component of both TORC1 and TORC2. TORC1 regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. TORC1 controls many of these processes via TIP41-TAP42-mediated inhibition of the type 2A-related phosphatases PP2A and SIT4 (PubMed:10198052, PubMed:10329624, PubMed:10604478, PubMed:11741537, PubMed:15620355, PubMed:7606777, PubMed:8741837, PubMed:9539725, PubMed:9843498). In nutrient rich conditions, responsible for the phosphorylation of AGC S6 kinase (S6K) YPK3, activating YPK3 kinase activity and promoting phosphorylation of ribosomal protein S6 (PubMed:25767889). Phosphorylates kinase SCH9 at 6 amino acids in the C-terminus, activating SCH9 kinase activity to properly regulate ribosome biogenesis, translation initiation, and entry into stationary phase (PubMed:17560372). TORC2 regulates cell cycle-dependent polarization of the actin-cytoskeleton, cell wall integrity, and receptor endocytosis. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway by activating the RHO1 guanine nucleotide exchange factor ROM2. TORC2 phosphorylates the AGC kinase YPK2, an upstream effector of the cell integrity pathway. TORC2 negatively regulates calcineurin-dependent stress signaling via phosphorylation of its effector SLM1-SLM2 (PubMed:14593073, PubMed:15372071, PubMed:16055732, PubMed:16959779, PubMed:8846782, PubMed:8943012). (From uniprot, under CC BY 4.0)
Product Overview	Mouse Anti-Yeast TOR2 Antibody is a mouse antibody against TOR2. It can be used for TOR2 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative Names	Serine/threonine-protein kinase TOR2; EC 2.7.1.67; EC 2.7.11.1; Dominant rapamycin resistance protein 2; Phosphatidylinositol 4-kinase TOR2; PI4-kinase TOR2; PI4K TOR2; PtdIns-4-kinase TOR2; Target of rapamycin kinase 2; Temperature-sensitive CSG2 suppres; TOR2; DRR2 TSC14; YKL203C
UniProt ID	P32600
Protein Refseq	The length of the protein is 2474 amino acids long. The sequence is show below: MNKYINKYTTPPNLLSLRQRAEGKHRTRKKLTHKSHSHDDEMSTTSNTDSNHNGPNDSGRVITGSAGHIGKISFVDSELDTTFSTLNLIFDKLKSDVPQERASGANELSTTLTSLAREVSAEQFQRFSNSLNNKIFELIHGFTSSEKIGGILAVDTLISFYLSTEELPNQTSRLANYLRVLIPSSDIEVMRLAANTLGRLTVPGGTLTSDFVEFEVRTCIDWLTLTADNNSSSSKLEYRRHAALLIIKALADNSPYLLYPYVNSILDNIWVPLRDAKLIIRLDAAVALGKCLTIIQDRDPALGKQWFQRLFQGCTHGLSLNTNDSVHATLLVFRELLSLKAPYLRDKYDDIYKSTMKYKEYKFDVIRREVYAILPLLAAFDPAIFTKKYLDRIMVHYLRYLKNIDMNAANNSDKPFILVSIGDIAFEVGSSISPYMTLILDNIREGLRTKFKVRKQFEKDLFYCIGKLACALGPAFAKHLNKDLLNLMLNCPMSDHMQETLMILNEKIPSLESTVNSRILNLLSISLSGEKFIQSNQYDFNNQFSIEKARKSRNQSFMKKTGESNDDITDAQILIQCFKMLQLIHHQYSLTEFVRLITISYIEHEDSSVRKLAALTSCDLFIKDDICKQTSVHALHSVSEVLSKLLMIAITDPVAEIRLEILQHLGSNFDPQLAQPDNLRLLFMALNDEIFGIQLEAIKIIGRLSSVNPAYVVPSLRKTLLELLTQLKFSNMPKKKEESATLLCTLINSSDEVAKPYIDPILDVILPKCQDASSAVASTALKVLGELSVVGGKEMTRYLKELMPLIINTFQDQSNSFKRDAALTTLGQLAASSGYVVGPLLDYPELLGILINILKTENNPHIRRGTVRLIGILGALDPYKHREIEVTSNSKSSVEQNAPSIDIALLMQGVSPSNDEYYPTVVIHNLMKILNDPSLSIHHTAAIQAIMHIFQNLGLRCVSFLDQIIPGIILVMRSCPPSQLDFYFQQLGSLISIVKQHIRPHVEKIYGVIREFFPIIKLQITIISVIESISKALEGEFKRFVPETLTFFLDILENDQSNKRIVPIRILKSLVTFGPNLEDYSHLIMPIVVRMTEYSAGSLKKISIITLGRLAKNINLSEMSSRIVQALVRILNNGDRELTKATMNTLSLLLLQLGTDFVVFVPVINKALLRNRIQHSVYDQLVNKLLNNECLPTNIIFDKENEVPERKNYEDEMQVTKLPVNQNILKNAWYCSQQKTKEDWQEWIRRLSIQLLKESPSACLRSCSSLVSVYYPLARELFNASFSSCWVELQTSYQEDLIQALCKALSSSENPPEIYQMLLNLVEFMEHDDKPLPIPIHTLGKYAQKCHAFAKALHYKEVEFLEEPKNSTIEALISINNQLHQTDSAIGILKHAQQHNELQLKETWYEKLQRWEDALAAYNEKEAAGEDSVEVMMGKLRSLYALGEWEELSKLASEKWGTAKPEVKKAMAPLAAGAAWGLEQWDEIAQYTSVMKSQSPDKEFYDAILCLHRNNFKKAEVHIFNARDLLVTELSALVNESYNRAYNVVVRAQIIAELEEIIKYKKLPQNSDKRLTMRETWNTRLLGCQKNIDVWQRILRVRSLVIKPKEDAQVRIKFANLCRKSGRMALAKKVLNTLLEETDDPDHPNTAKASPPVVYAQLKYLWATGLQDEALKQLINFTSRMAHDLGLDPNNMIAQSVPQQSKRVPRHVEDYTKLLARCFLKQGEWRVCLQPKWRLSNPDSILGSYLLATHFDNTWYKAWHNWALANFEVISMLTSVSKKKQEGSDASSVTDINEFDNGMIGVNTFDAKEVHYSSNLIHRHVIPAIKGFFHSISLSESSSLQDALRLLTLWFTFGGIPEATQAMHEGFNLIQIGTWLEVLPQLISRIHQPNQIVSRSLLSLLSDLGKAHPQALVYPLMVAIKSESLSRQKAALSIIEKMRIHSPVLVDQAELVSHELIRMAVLWHEQWYEGLDDASRQFFGEHNTEKMFAALEPLYEMLKRGPETLREISFQNSFGRDLNDAYEWLMNYKKSKDVSNLNQAWDIYYNVFRKIGKQLPQLQTLELQHVSPKLLSAHDLELAVPGTRASGGKPIVKISKFEPVFSVISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLQNDAECFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHREAKKIPLNIEHWVMLQMAPDYDNLTLLQKVEVFTYALNNTEGQDLYKVLWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKFPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMKVLRDNKGSLMAILEAFAFDPLINWGFDLPTKKIEEETGIQLPVMNANELLSNGAITEEEVQRVENEHKNAIRNARAMLVLKRITDKLTGNDIRRFNDLDVPEQVDKLIQQATSVENLCQHYIGWCPFW.