Mouse Anti-ndfip2 Antibody (CBMOAB-88548FYA)
Cat: CBMOAB-88548FYA
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
- Product List
- Specifications
- Application Information
- Target
| Sub Cat | Clonality | Species Reactivity | Application | Clone | Conjugate | Size | |
| CBMOAB-88548FYA | Monoclonal | Zebrafish (Danio rerio), Cattle (Bos taurus), Frog (Xenopus laevis), Marmoset, Rhesus (Macaca mulatta) | WB, ELISA | MO88548FYA | 100 µg | ||
| MO-AB-04630W | Monoclonal | Rhesus (Macaca mulatta) | WB, ELISA | MO04630W | 100 µg | ||
| MO-AB-05507H | Monoclonal | Frog (Xenopus laevis) | WB, ELISA | MO05507C | 100 µg | ||
| MO-AB-16554R | Monoclonal | Cattle (Bos taurus) | WB, ELISA | MO16554R | 100 µg | ||
| MO-AB-59840W | Monoclonal | Marmoset | WB, ELISA | MO59840W | 100 µg |
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Zebrafish (Danio rerio), Cattle (Bos taurus), Frog (Xenopus laevis), Marmoset, Rhesus (Macaca mulatta) |
| Clone | MO88548FYA |
| Specificity | This antibody binds to Zebrafish ndfip2. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Golgi apparatus; Endoplasmic reticulum; Other locations |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination. (From uniprot, under CC BY 4.0) |
| Product Overview | Mouse Anti-Zebrafish ndfip2 Antibody is a mouse antibody against ndfip2. It can be used for ndfip2 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | ndfip2; Nedd4 Family Interacting Protein 2 |
| UniProt ID | F1QYW5 |
| Protein Refseq | The length of the protein is 237 amino acids long. The sequence is show below: MKMDQAASRYQVLHNEDDSSEGAASAEPSTSTQAVGALEGISNLAVDTEAPPPPYASVALGATAAPESTFAGDFPVPPPYSIATSLPTYDEAEKAKAAAMAASAVEVIPRDEDFPVRDDFSDADQLRVGNDGIFMLAFFMAFLFNWIGFCLSFCLTNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSESMVSSLRTRFFLLY. |
For Research Use Only | Not For Clinical Use.
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