B-Cell Leukemia/Lymphoma 2

Bcl-2 (B-cell lymphoma 2), a founding member of the Bcl-2 family of regulatory proteins, regulates cell death (apoptosis) by inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis. In mammals, it has been linked to non-Hodgkin lymphoma, which normally helps regulate the lifespan of white blood cells but, when mutated, prevents these cells from dying, potentially leading to further mutations and cancer development of.