BRCA1 homologue
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
Mouse Anti-BRCA1 Antibody (CBMOAB-25468FYC) (CAT#: CBMOAB-25468FYC)
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- Host species: Mouse
- Species Reactivity: A. thaliana (Arabidopsis thaliana), Cattle (Bos taurus), Chicken (Gallus gallus), Chimpanzee (Pan troglodytes), Dog (Canis lupus familiaris), Donkey (Equus asinus), Ferret (Mustela Putorius Furo), Frog (Xenopus laevis), Hamsters (Cricetinae), Horse (Equus caballus), Marmoset, Pig (Sus scrofa), Purple sea urchin (Strongylocentrotus purpuratus), Rabbit (Oryctolagus cuniculus), Rhesus (Macaca mulatta), Sheep (Ovis aries)
- Application: WB, ELISA
- Protein: Protein BREAST CANCER SUSCEPTIBILITY 1 homolog
- Size: 0.5mg, 1mg, 200µg
- Conjugate: AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, None, PE, PerCP
- Alternative Names: BRCA1, DNA Repair Associated, Protein Phosphatase 1, Regulatory Subunit 53, BRCA1/BRCA2-Containing Complex, Subunit 1, Fanconi Anemia, Complementation Group S, Breast Cancer 1, Early Onset, RING Finger Protein 53, RNF53, Breast And Ovarian Cancer Susceptibility Protein 1, Breast Cancer Type 1 Susceptibility Protein, RING-Type E3 Ubiquitin Transferase BRCA1, Early Onset Breast Cancer 1, Breast Cancer 1
