Mouse Anti-AFF1 Antibody (CBMOAB-00426HCB)
Cat: CBMOAB-00426HCB
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
- Product List
- Specifications
- Application Information
- Target
| Sub Cat | Clonality | Species Reactivity | Application | Clone | Conjugate | Size | |
| CBMOAB-00426HCB | Monoclonal | C. elegans (Caenorhabditis elegans), Chimpanzee (Pan troglodytes), Marmoset, Rhesus (Macaca mulatta) | WB, ELISA | MO00426HB | 100 µg | ||
| CBMOAB-35285FYA | Monoclonal | Rhesus (Macaca mulatta) | WB, ELISA | MO35285FYA | 100 µg | ||
| MO-AB-00960W | Monoclonal | Rhesus (Macaca mulatta) | WB, ELISA | MO00960W | 100 µg | ||
| MO-AB-11970W | Monoclonal | Chimpanzee (Pan troglodytes) | WB, ELISA | MO11970W | 100 µg | ||
| MO-AB-50552W | Monoclonal | Marmoset | WB, ELISA | MO50552W | 100 µg |
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | C. elegans (Caenorhabditis elegans), Chimpanzee (Pan troglodytes), Marmoset, Rhesus (Macaca mulatta) |
| Clone | MO00426HB |
| Specificity | This antibody binds to C. elegans AFF1. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Plasma Membrane; Other locations; Extracellular region or secreted |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. |
| Product Overview | Mouse Anti-C. elegans AFF1 Antibody is a mouse antibody against AFF1. It can be used for AFF1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Anchor cell fusion failure-1; Protein AFF-1; aff-1 |
| Gene ID | 174123 |
| UniProt ID | G5EGL9 |
| Protein Refseq | The length of the protein is 589 amino acids long. The sequence is show below: MRLWQWSIAVAICLVMVTEARLRRHHRKRRFVSSNFDEFYCGESAHAQSQFEEERESNSSKVSSVHSTQFNWGLDNTICIKLQNVVHVLKYERLEQRYPIENSYTFSVPLIDTNCKCHCYGFGTNDVCNVEKYADDRNCTTSSEFPTCYTKYHPAVEPLDCPVTSIPAKACCDIKLKPRDGRMFRAVKLQQPINDMIISHSIFANNSGKMMKVLGPDEFRINLLKGKEQFELTEYHRISVQLVASSPQQQLREGMYYFPEENHNDLREGKINEITESDLDKLGWYRRVGNDWQVATSGLLLRNAHKVVIKNCKGQVHMDQFSGTKNFVLRGTQYNDTYNERRVSDNNFVRSVKVDESSREITIVHEHGTAAQVSLKTDTRPNLTKSQSLLANFTGSITLDHDGNRMLNVTFFGVKGTVHIKMYVNDRKLIATFACTAQFGTSLKDDGSRISLPSTINQAQWVCILPDEQPTKSEICKWIPYEEKAMRTPRQEQSWSKGHSPCSQAECNSLKSGVSDLFPWIMNFDYFMAHGGDFTEWLKIGIHIVIAVGLLLLLILLFTKCLVPLACCSLSIPFKNRNKKKKKKNSSDY. |
For Research Use Only | Not For Clinical Use.
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