Mouse Anti-APC2 Antibody (CBMOAB-00246CR)


Cat: CBMOAB-00246CR
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Lot Number

  • Product List
  • Specifications
  • Application Information
  • Target
Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
CBMOAB-00246CR Monoclonal Yeast, A. thaliana (Arabidopsis thaliana), Arabidopsis (Arabidopsis lyrata), C. elegans (Caenorhabditis elegans), Fruit fly (Drosophila melanogaster), Marmoset, Pig (Sus scrofa), Rhesus (Macaca mulatta), Zebrafish (Danio rerio) WB, ELISA MO00246CR 100 µg
CBMOAB-00557HCB Monoclonal C. elegans (Caenorhabditis elegans) WB, ELISA MO00557HB 100 µg
CBMOAB-01095FYA Monoclonal Fruit fly (Drosophila melanogaster) WB, ELISA MO01095FYA 100 µg
CBMOAB-2256FYC Monoclonal A. thaliana (Arabidopsis thaliana) WB, ELISA MO2256FC 100 µg
CBMOAB-35988FYA Monoclonal Rhesus (Macaca mulatta) WB, ELISA MO35988FYA 100 µg
CBMOAB-66104FYA Monoclonal Zebrafish (Danio rerio) WB, ELISA MO66104FYA 100 µg
MO-AB-00070H Monoclonal Arabidopsis (Arabidopsis lyrata) WB, ELISA MO00070C 100 µg
MO-AB-03375W Monoclonal Rhesus (Macaca mulatta) WB, ELISA MO03375W 100 µg
MO-AB-23784R Monoclonal Pig (Sus scrofa) WB, ELISA MO23784R 100 µg
MO-AB-51067W Monoclonal Marmoset WB, ELISA MO51067W 100 µg
MO-DKB-02296W Polyclonal A. thaliana (Arabidopsis thaliana) IP, IF 100 µg

Specifications

Host speciesMouse (Mus musculus)
Species ReactivityYeast, A. thaliana (Arabidopsis thaliana), Arabidopsis (Arabidopsis lyrata), C. elegans (Caenorhabditis elegans), Fruit fly (Drosophila melanogaster), Marmoset, Pig (Sus scrofa), Rhesus (Macaca mulatta), Zebrafish (Danio rerio)
CloneMO00246CR
SpecificityThis antibody binds to Yeast APC2.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationNucleus; Other locations

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionComponent of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.
Product OverviewMouse Anti-Yeast APC2 Antibody is a mouse antibody against APC2. It can be used for APC2 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesAnaphase-promoting complex subunit 2; APC2; RSI1; YLR127C
UniProt IDQ12440
Protein RefseqThe length of the protein is 853 amino acids long. The sequence is show below: MSFQITPTRDLKVITDELQTLSSYIFHTNIVDDLNSLLTWMSPNDAKSNHQLRPPSLRIKNIIKVLFPNNATTSPYSMINTSQANNSIVNEGNTNKELQLQLFSTLKEFYIFQVRYHFFLHFNNINYLKDIQRWENYYEFPLRYVPIFDVNVNDWALELNSLRHYLLNRNIKFKNNLRTRLDKLIMDDDFDLADNLIQWLKSANGSLSSTELIVNALYSKINKFCEDNMSRVWNKRFMIMETFNKFINQYWSQFSKLVGCPEDDHELTTTVFNCFESNFLRIRTNEIFDICVLAYPDSKVTLLELRKIMKDFKDYTNIVTTFLSDFKKYILNPSVTTVDALLRYVKTIKAFLVLDPTGRCLHSITTFVKPYFQERKHLVNVLLYAMLDLPEEELKEKINFNVDMKALLSLVDTLHDSDINQDTNITKRDKNKKSPFLWNLKVKGKRELNKDLPIRHAMLYEHILNYYIAWVPEPNDMIPGNIKSSYIKTNLFEVLLDLFESREFFISEFRNLLTDRLFTLKFYTLDEKWTRCLKLIREKIVKFTETSHSNYITNGILGLLETTAPAADADQSNLNSIDVMLWDIKCSEELCRKMHEVAGLDPIIFPKFISLLYWKYNCDTQGSNDLAFHLPIDLERELQKYSDIYSQLKPGRKLQLCKDKGKVEIQLAFKDGRKLVLDVSLEQCSVINQFDSPNDEPICLSLEQLSESLNIAPPRLTHLLDFWIQKGVLLKENGTYSVIEHSEMDFDQAQKTAPMEIENSNYELHNDSEIERKYELTLQRSLPFIEGMLTNLGAMKLHKIHSFLKITVPKDWGYNRITLQQLEGYLNTLADEGRLKYIANGSYEIVKNGHKNS.
For Research Use Only | Not For Clinical Use.
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