AibGenesis™ Mouse Anti-babam1 Antibody (CBMOAB-67360FYA)


Cat: CBMOAB-67360FYA

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Lot Number

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  • Specifications
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Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
CBMOAB-67360FYA Monoclonal Zebrafish (Danio rerio), Cattle (Bos taurus), Chimpanzee (Pan troglodytes), Human (Homo sapiens), Rhesus (Macaca mulatta), Marmoset WB, ELISA MO67360FYA 100 µg
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MO-AB-07945R Monoclonal Cattle (Bos taurus) WB, ELISA MO07945R 100 µg
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MO-AB-16961W Monoclonal Chimpanzee (Pan troglodytes) WB, ELISA MO16961W 100 µg
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MO-AB-51707W Monoclonal Marmoset WB, ELISA MO51707W 100 µg
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MO-NAB-00220W Monoclonal Human (Homo sapiens), Rhesus (Macaca mulatta) WB, IF NW0013 100 µg
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityZebrafish (Danio rerio), Cattle (Bos taurus), Chimpanzee (Pan troglodytes), Human (Homo sapiens), Rhesus (Macaca mulatta), Marmoset
CloneMO67360FYA
SpecificityThis antibody binds to Zebrafish babam1.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationNucleus; Other locations

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionComponent of the BRCA1-A complex, a complex that specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the Lys-63-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). (From uniprot, under CC BY 4.0)
Product OverviewMouse Anti-Zebrafish babam1 Antibody is a mouse antibody against babam1. It can be used for babam1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesBRISC and BRCA1-A complex member 1; Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex; babam1; merit40 nba
UniProt IDQ6AXK4
Protein RefseqThe length of the protein is 370 amino acids long.
The sequence is show below: METTEPGQADGEERMMDLRPRTRSNPEGAEDRRSSTGSLNSSLPSAPQPAVGSRVEGEGEAASSDSPPVSATAIAATASVPVAAVGNTTTTNTASLPAMSPAVKERPKPSQPTMPTQIPPSAELHLRAPRVNCPEKVIICLDLSEEMSLQKLESINGSKTNALNISQKMIEMFVRTKHKIDKRHEFALVVVNDDAMWLSGFTSDPRELCSCLYDLETNVCESFNLEDLFNVILQKIELPQMENIQTIPPPFVVRTLLVFSRHAGMLQFNPSDAVKKMLQSPYFFFDVVFLHNGTEEQTEDTSWKDVYASFCELDTKGMCYRFEVSLCGPAIELHNCMAKLLCHPLQRPFQSHASYSLLEDEDTLENEATV.
For Research Use Only | Not For Clinical Use.
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