Mouse Anti-C. elegans ATG18 Antibody (CBMOAB-00746HCB)
Cat: CBMOAB-00746HCB
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | C. elegans (Caenorhabditis elegans) |
| Clone | MO00746HB |
| Specificity | This antibody binds to C. elegans ATG18. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Cytosol; Other locations |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P-granules in somatic cells (PubMed:12958363, PubMed:19167332, PubMed:21183797, PubMed:21802374, PubMed:22451698, PubMed:25124690, PubMed:28557996). In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdInsP), phosphatidylinositol 4-phosphate (PtdInsP), and phosphatidylinositol 5-phosphate (PtdInsP), and more weakly to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:21802374, PubMed:22451698). Plays a role in mitophagy, which is the autophagic consumption of mitochondria, in response to dietary restriction (PubMed:30133321). In a daf-18/PTEN- and daf-16/FOXO-dependent manner, required for the proliferation of germ stem cell progenitors in the gonad during the late phases of larval development (PubMed:28285998). By regulating the release of neurotransmitters and neuropeptides, involved in the control of lifespan in response to dietary restriction and daf-2 signaling (PubMed:28557996). Probably through its involvement in autophagy, required for dauer formation (PubMed:12958363). |
| Product Overview | Mouse Anti-C. elegans ATG18 Antibody is a mouse antibody against ATG18. It can be used for ATG18 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Autophagy-related protein 18, isoform a; atg-18 |
| Gene ID | 179246 |
| UniProt ID | O16466 |
| Protein Refseq | The length of the protein is 412 amino acids long. The sequence is show below: MSATTSEENPDSINYIGFNQDSKVICVGHKDGYMFYKTADILENNTLTYEGENLTHLGLNNCLIIERLFSSALMVVISQKDPRVLHVYHFTSRNIICDHRFNKSVLTVRLNRDRIVVCLEDCIYIYNLKDMKMMHNIMDTPTNKLGVLDLTSNPGNALIAYPGSTDTGSVHLFDAINLSSVSTFNAHEGTIACLKFNQEGNMIATASTKGTVIRVYSVPNGHRLFEFRRGVTRCVNIYSLCFSSDSKYLTSSSNTETVHVFKLEKTEGVDNKPEASTEGGGWFDAINKTFSAYMPSQVLQVGELMTTERSFATAKLPGAARSNQVSLVSHKNQQYVMAATSDGFVYAYRLDPEGGELDLIKQHNIGPKSDTSRASPTSTGSGGAAKSAEASNQSVPNMDDPDDFPPMSHTSG. |
See other products for " ATG18 "
| CBMOAB-00375CR | Mouse Anti-Yeast ATG18 Antibody (CBMOAB-00375CR) |
For Research Use Only | Not For Clinical Use.
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