Cat: CBMOAB-00815HCB
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | C. elegans (Caenorhabditis elegans) |
| Clone | MO00815HB |
| Specificity | This antibody binds to C. elegans ATX3. |
| Format | Lyophilized |
| Storage | Store at 4°C: short-term (1-2 weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Nucleus; Other locations |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway (PubMed:19545544, PubMed:17234717, PubMed:21317884). Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan (PubMed:21317884). Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci (PubMed:27669035). Interacts with key regulators of transcription and represses transcription (By similarity). Acts as a histone-binding protein that regulates transcription (By similarity). |
| Product Overview | Mouse Anti-C. elegans ATX3 (clone MO00815HB) Antibody (CBMOAB-00815HCB) is a mouse antibody against ATX3. It can be used for ATX3 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Ataxin-3 homolog; EC 3.4.19.12; Machado-Joseph disease-like protein; atx-3 |
| UniProt ID | O17850 |
| Protein Refseq | The length of the protein is 317 amino acids long. The sequence is show below: MSKDDPINSIFFEHQEAALCAQHALNMLLQDALYKWQDLRDLAIQMDKMEQQILGNANPTPGRSENMNESGYFSIQVLEKALETFSLKLTNIENPAMVDYKNNPLTARAYICNLREHWFVLRKFGNQWFELNSVNRGPKLLSDTYVSMFLHQVSSEGYSIFVVQGVLPRSDADDLISLCPVVPPKVTPKKEQKLEKVMTKFFNTVGKRLGGGSGAPPDSQEEKDLAIAFAMSMETKDGSEVSRSSAEIDEENLRKAIELSQAPGPSEPAEIPLLTRSRSSTPPGASEPFSNAEQQRRDRQKFLERFEKKKEERNDEK. |
See other products for " ATX3 "
| CBMOAB-24941FYC | Mouse Anti-Arabidopsis ATX3 Antibody (CBMOAB-24941FYC) |
| CBMOAB-24940FYC | Mouse Anti-Arabidopsis ATX3 Antibody (CBMOAB-24940FYC) |
For Research Use Only | Not For Clinical Use.