Mouse Anti-C. elegans BEC1 Antibody (CBMOAB-00893HCB)
Cat: CBMOAB-00893HCB
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- Specifications
- Application Information
- Target
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | C. elegans (Caenorhabditis elegans) |
| Clone | MO00893HB |
| Specificity | This antibody binds to C. elegans BEC1. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Endosome; Nucleus; Other locations |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Regulates autophagy (PubMed:12958363). Together with phosphatidyl-3-phosphate kinase vps-34, acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate (PtdIns3P), thereby regulating membrane trafficking (PubMed:16111945, PubMed:21183797, PubMed:26783301). In association with sorf-1 and sorf-2, negatively regulates phosphatidylinositol 3-phosphate in early endosomes to allow for the conversion to late endosomes (PubMed:26783301). Involved in the clearance of engulfed apoptotic cell corpses (PubMed:16111945, PubMed:21183797). Together with ced-9, negatively regulates somatic and germline apoptosis (PubMed:17890369). Plays a role in endosome-to-Golgi retrograde transport of mig-14 (PubMed:21183797). In a daf-18/PTEN- and skn-1/Nrf-dependent manner, promotes germline stem cell proliferation during late and adult stages, probably by ensuring cell survival and cell cycle progression (PubMed:28285998). Required for embryonic development and L3/L4 molting during larval development (PubMed:16111945). Required for normal dauer morphogenesis and lifespan (PubMed:12958363, PubMed:17204841). Plays a role in male tail ray pattern formation (PubMed:17890369). Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium (PubMed:19667176). (From uniprot, under CC BY 4.0) |
| Product Overview | Mouse Anti-C. elegans BEC1 Antibody is a mouse antibody against BEC1. It can be used for BEC1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Protein BEC-1, isoform a; bec-1 |
| UniProt ID | Q22592 |
| Protein Refseq | The length of the protein is 375 amino acids long. The sequence is show below: MTTQRSHICLNCQHPLRLDFTQRRPDSADSEKKSETVITEALTGHSRNLMKLISDAQFPSDAPVCNDCSDALRNEMDAQVATLDDEIKTYQTYINYLKENHPTTSIPDLKAKLQNVSDEEKELEQQLKKLLAEEEQLDLDLQTKRRTAEAASEKSGELWKKYRDNLRQVFEDQDELHSLEAERQYAEVQHRKLTDTNVLDLCFHIWVDGIVGEINGFRLGYLKDAPVEFTEINAALGQIVLLLEILLERIGVQHHELMPVAMGSHSYIKLRRNGIDMETYALYGQGTPLSGSSGIDPGIRRFLQLLEFLLKELKDRNKNFKPPYQIHADSLVDNGVKYNAVMTLNTDVRWTRAMALMLTDLKAACAQCDALRSPI. |
For Research Use Only | Not For Clinical Use.
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