AibGenesis™ Mouse Anti-GBB2 Antibody (CBMOAB-04280HCB)


Cat: CBMOAB-04280HCB

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Lot Number

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Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
CBMOAB-04280HCB Monoclonal C. elegans (Caenorhabditis elegans), Medaka (Oryzias latipes) WB, ELISA MO04280HB 100 µg
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MO-AB-00577R Monoclonal Medaka (Oryzias latipes) WB, ELISA MO00577R 100 µg
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityC. elegans (Caenorhabditis elegans), Medaka (Oryzias latipes)
CloneMO04280HB
SpecificityThis antibody binds to C. elegans GBB2.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationPlasma Membrane

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionComponent of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2. Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Along with gbb-1, may couple to the G(o) alpha G-protein goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of acetylcholine in ventral cord motor neurons (PubMed:18614679). As acetylcholine depolarizes body wall muscles, modulation of acetylcholine levels most likely results in the control of locomotory behavior (PubMed:18614679). Regulates locomotory behavior in response to GABA release by GABAergic motor neurons (PubMed:18614679, PubMed:21613582). (From uniprot, under CC BY 4.0)
Product OverviewMouse Anti-C. elegans GBB2 Antibody is a mouse antibody against GBB2. It can be used for GBB2 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesGABAB2 receptor subunit; Protein GBB-2; gbb-2
UniProt IDG5ECB2
Protein RefseqThe length of the protein is 842 amino acids long. The sequence is show below: MSRWLSLLLFAVQAVGGYEAGEELSCKRRHGGIPLPLGVFTVQKEGFPDALPAIRTALSHVHSRSCILQGYRLEMIVKDTHCKTSQGMKALFDLIASRPRPVAILGGQCTEVNEPIAMALKYWQIVQLSYAETHAKFASSDSHELFTTFFRVVPGSRNTNMAKCKFVNHFGWKRVGTVKQNDQPRYALPHEALTTRLEHGFGVKIVHTAGVNWEQIETVGGELDELKERDVRIILVDVDEEMAATVLCAGYHRGMYGDNYVWILPGYHSDKWLNQTHDNCTVEEMREAAKNHFSVEFALTRRDVDTKIVGNTRAGDVWNEITQLDPNNTWRGYLYDGLWTLAIALSHSMGDNAEFSHHKMMEAIDNSSFQGLTGKVKFANNERLGLVDIKQWSDGQYVPFAVYDGADDEFKIIDSTTKGWSPPLDSTITERRREHISSILFLAMSLLALIGIFLALIFLLINFRYRNHRFIKMSSPNLNNIIIAGSICTFASVIMLGLDTRIVSPDVFVWLCYTKTWTLCIGFTLSFGAMFSKTWRVHSIFTNIRMDRKAIKDSKLFIILGILLFIDICVLVTWAFVSPFSYTVTELPHIPEDNIVIIPEVEKCNSSHSGVFQAVLYAVKGVLMILGCFLAWETRHVNVPALNDSKYIGTSVYCCVVMSVLGLSTSVILQERVNEMFSLASFFVIFSTTLTLCLVFVPKVIELARNPVGNEPRAYRRGLMKSVVAKTSQPMSPQPRSDSSGDLIGKAESENKLRRRYLHQKSTQLWDLVEKLRAQGDTRFLQQEWCLSSASPSSQERETSLLLRQPSSSNNREETSLTAAGPNGERSSDWPWVDPDEPSTKL.
For Research Use Only | Not For Clinical Use.
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