Cat: MOFAB-152W
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product Details
Specifications
| Host species | Rabbit |
| Species Reactivity | Helicobacter pylori |
| Clone | WHP1811 |
| Specificity | This antibody recognizes an epitope between Asp562 and Gln795 of H. pylori Cag A protein. |
| Immunogen | Recombinant fragment of Helicobacter pylori CagA protein. |
| Format | Liquid or Lyophilized |
| Buffer | PBS, pH 7.4 |
| Regulatory Status | For Research Use Only |
| Shipping | Gel Pack |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purification | Protein A |
Application Information
| Application | ELISA, IB |
| Application Notes | The optimal dilution should be determined by the end user. |
Target
| Introduction | Helicobacter pylori was initially associated with peptic ulcer disease and is now also associated with gastric cancer. A study of H. pylori genes and antigens by Backert and Blaser identified the 128kDa CagA protein (the product of the cagA gene) as a protein associated with an increased risk of gastric cancer. During infection, CagA localizes to the host plasma membrane and undergoes tyrosine phosphorylation. Subsequently, various forms of CagA interact with more than 25 host signaling factors to promote alterations in pro-inflammatory, proliferative, cell cycle-related and anti-apoptotic genes. Changes in cell growth and epithelial integrity by CagA can trigger precancerous changes in the stomach, which is one explanation for the high incidence of gastric cancer in patients with CagA+H. Helicobacter pylori. |
| Product Overview | The cagA antibody is used as Infectious Disease Antibodies. |
| Alternative Names | Helicobacter pylori CagA protein; cagA; type IV secretion system oncogenic effector CagA; Helicobacter pylori CagA protein |
Reference
For Research Use Only | Not For Clinical Use.