Mouse Anti-CSN5 Antibody (CBMOAB-02214HCB)
Cat: CBMOAB-02214HCB
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
- Product List
- Specifications
- Application Information
- Target
| Sub Cat | Clonality | Species Reactivity | Application | Clone | Conjugate | Size | |
| CBMOAB-02214HCB | Monoclonal | C. elegans (Caenorhabditis elegans), Fruit fly (Drosophila melanogaster), O. mykiss (Oncorhynchus mykiss), Tomato (Lycopersicon esculentum) | WB, ELISA | MO02214HB | 100 µg | ||
| CBMOAB-14204FYA | Monoclonal | Fruit fly (Drosophila melanogaster) | WB, ELISA | MO14204FYA | 100 µg | ||
| MO-AB-11089Y | Monoclonal | O. mykiss (Oncorhynchus mykiss) | WB, ELISA | MO11089Y | 100 µg | ||
| MO-AB-34327H | Monoclonal | Tomato (Lycopersicon esculentum) | WB, ELISA | MO34327C | 100 µg |
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | C. elegans (Caenorhabditis elegans), Fruit fly (Drosophila melanogaster), O. mykiss (Oncorhynchus mykiss), Tomato (Lycopersicon esculentum) |
| Clone | MO02214HB |
| Specificity | This antibody binds to C. elegans CSN5. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Nucleus; Other locations |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity). The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3. May stabilize glh-1 protein levels by antagonizing kgb-1 (PubMed:17699606). |
| Product Overview | Mouse Anti-C. elegans CSN5 Antibody is a mouse antibody against CSN5. It can be used for CSN5 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | COP9 signalosome complex subunit 5; Signalosome subunit 5; JAB1 homolog; csn-5 |
| UniProt ID | P91001 |
| Protein Refseq | The length of the protein is 368 amino acids long. The sequence is show below: MEVDNVKPSSSVPQRNWEKENNVQNVDSIFEYNNKQQVEIRNAKPWDKDPHYFKQIKISAIALLKMTMHAKRGGNLEIMGLLQGRIDANSFIILDVFALPVEGTETRVNAQAQAYEYMTVYSEMCDTEGRKEKVVGWYHSHPGYGCWLSGIDVSTQTLNQKFQEPWVAIVIDPLRTMSAGKVDIGAFRTYPEGYRPPDDVPSEYQSIPLAKIEDFGVHCKRYYSLDVSFFKSQLDAHILTSLWNSYWISTLSSSPLFSNVEFLNNQIQDINQKLSAVDKKLQLNDRSVDGHEALMKVVTDAKAVGDELETGRISHLVKQLLFARQAGGGCGCSHASAGSPMDIAVATEPEKAGPSPSAPEPAVEMADA. |
For Research Use Only | Not For Clinical Use.
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