Mouse Anti-D. melanogaster Alk Antibody (CBMOAB-00872FYA)
Cat: CBMOAB-00872FYA
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Fruit fly (Drosophila melanogaster) |
| Clone | MO00872FYA |
| Specificity | This antibody binds to fruit fly Alk. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Plasma Membrane; Other locations |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X). |
| Product Overview | Mouse Anti-D. melanogaster Alk Antibody is a mouse antibody against Alk. It can be used for Alk detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Alk; EC 2.7.10.-; EC 2.7.10.1; Receptor protein tyrosine kinase ALK splice variant A; Alk |
| UniProt ID | Q7KJ08 |
| Protein Refseq | The length of the protein is 1701 amino acids long. The sequence is show below: MPQLRQLVVVLAILSLLVDPSFAQRPLIMNHTFSSLPMSQHPSFNSWPSASGGKQLRNGRLHEQPLPLPQPTLPVATQYEDYEAAPPGSRRDNKRRLAQMAQRPGSGNGGRRGMESLRKELMNPSVGGPGGGISGGGSGYPSYSATSSIGRIDGLGQGLGSADRYGALYDQLRQPSGMAAMTAGPLGGPYSTRFPPLYAGVDDQPKRSNRKNSISELYKLKKALNQADEPAGGVTHGNFEGDPQPSSADPLQEIKDRIRDTSPNANTYAPHTDATPSSEYEYELGVKCNFETPCSWTWGNYSDGFQVITGTELSKRNLTGLLPGPAADSIDDANGHFLYARVNPSSRPLNLTSPEFSTTMEKCFLEVYMHQSDMSHGLSRVVVELLHTAESSWVPAEILGDNVRQWTRKVYRLGRVSRDFRIVFEVVPDLRVGQKGHVALDNLRMVNCFPEGTKSEKCSTSQVKCTSSKVPVCIHLPRICDITRDCDEAEDEQQSCDKIPYGGRCDFEEDWCGWRDSGKTTLTWSRHTGSSPTHDTGPDGDHTMQHLQNNTSGYYMLVNMNQHMNNSEKNSIIGFASNAIMVSKTFNPPPSVHGNPDSPYRNSCVVRFFIHQFGKNPGSINLSVVEMKEKENITTTLWWSTKNQGSDWMRAEYVLPNITSKYYLQFEARMGMRIYSDVAVDDFSLSPECFGLNIPEDHLGGYNYWDVRQNLKSPTYKDFEYTNYLELTTCDTRGMIGPSQAQCEAAYREQNKTHVLREVHVVEDQSSYKGMQKWKVPHEGHYTIIAKGASGGLGSGGVGSSRGSVAVAILELHKNEELYFLVGQQGENACIKSMGVLKEAGCGTDHDLDLAQYSFRSKQDMVKNIYIENGAGGGGGGSYVFLLNQAKNEAVPLLVAGGGGGLGIGQYIDEDFQHGQKAKPLQAPESGQINGEPLNKKTAGPGGGWRAKEDQALSPTYGAALLQGGRGGHSCYVELADNGTSVHRHGQGGFGGGGGGCNTGGGGGGYAGGDVYLTESNGEGGSSYISPSRSLREISEIHAGASSGPGAIIIIPAIEGCGCDYRCVALDEFRSKVRCICPDGWSLKRDNHTACEIREEAGKSSFQYLVSILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLPNILGPTASERDDTVIRPPNGEEFCLAVPDYLVPLPPGGSNNPSMASGSGYVPELQRQQMSSCTPPAVTSPAAPHPRPVENIAPTSGDCWETSFILPNSKVEPPVVGSGHDVPLAGGEEAKLISLDTPQPTPTTIQPPLSFASQLDGITLDPSALTKSLPNGNAKQSYANVQVKNEAEAKVINGVVGNGTVMNGDVSTGSGGADSPFTIQGYAERYKDNNNHSEISC. |
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For Research Use Only | Not For Clinical Use.
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