Certificate of Analysis Lookup
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Protein Refseq: The length of the protein is 664 amino acids long. The sequence is show below: MAEYLQPGVIRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQVQVKAGGLKLLQIQDNGTGIRREDLAIVCERFTTSKLTRFEDLSQIATFGFRGEALASISHVAHLSIQTKTAKEKCGYKATYADGKLQGQPKPCAGNQGTIICIEDLFYNMPQRRQALRSPAEEFQRLSEVLARYAVHNPRVGFTLRKQGDAQPALRTPVASSRSENIRIIYGAAISKELLEFSHRDEVYKFEAECLITQVNYSAKKCQMLLFINQRLVESTALRTSVDSIYATYLPRGHHPFVYMSLTLPPQNLDVNVHPTKHEVHFLYQEEIVDSIKQQVEARLLGSNATRTFYKQLRLPGAPDLDETQLADKTQRIYPKEMVRTDSTEQKLDKFLAPLVKSDSGVSSSSSQEASRLPEESFRVTAAKKSREVRLSSVLDMRKRVERQCSVQLRSTLKNLVYVGCVDERRALFQHETRLYMCNTRSFSEELFYQRMIYEFQNCSEITISPPLPLKELLILSLESEAAGWTPEDGDKAELADGAADILLKKAPIMREYFGLRISEDGMLESLPSLLHQHRPCVAHLPVYLLRLATEVDWEQETRCFETFCRETARFYAQLDWREGATAGFSRWTMEHVLFPAFKKYLLPPPRIKDQIYELTNLPTLYKVFERC.
Protein Refseq: The length of the protein is 737 amino acids long. The sequence is show below: MIDDSSLTAEMEEEESPATTIVPREPPKIQRLEESVVNRIAAGEVIQRPVSAVKELVENSLDADSSSISVVVKDGGLKLIQVSDDGHGIRREDLPILCERHTTSKLTKFEDLFSLSSMGFRGEALASMTYVAHVTVTTITKGQIHGYRVSYRDGVMEHEPKACAAVKGTQIMVENLFYNMIARRKTLQNSADDYGKIVDLLSRMAIHYNNVSFSCRKHGAVKADVHSVVSPSRLDSIRSVYGVSVAKNLMKVEVSSCDSSGCTFDMEGFISNSNYVAKKTILVLFINDRLVECSALKRAIEIVYAATLPKASKPFVYMSINLPREHVDINIHPTKKEVSLLNQEIIIEMIQSEVEVKLRNANDTRTFQEQKVEYIQSTLTSQKSDSPVSQKPSGQKTQKVPVNKMVRTDSSDPAGRLHAFLQPKPQSLPDKVSSLSVVRSSVRQRRNPKETADLSSVQELIAGVDSCCHPGMLETVRNCTYVGMADDVFALVQYNTHLYLANVVNLSKELMYQQTLRRFAHFNAIQLSDPAPLSELILLALKEEDLDPGNDTKDDLKERIAEMNTELLKEKAEMLEEYFSVHIDSSANLSRLPVILDQYTPDMDRVPEFLLCLGNDVEWEDEKSCFQGVSAAIGNFYAMHPPLLPNPSGDGIQFYSKRGESSQEKSDLEGNVDMEDNLDQDLLSDAENAWAQREWSIQHVLFPSMRLFLKPPASMASNGTFVKVASLEKLYKIFERC.
Protein Refseq: The length of the protein is 577 amino acids long. The sequence is show below: MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKGPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEIVGRYSIHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTASLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQTQAIVPEDKTDISSGRARQQDEEMLELPSPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINERGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLS.
Protein Refseq: The length of the protein is 725 amino acids long. The sequence is show below: MMAGVIRRLDETVVNRIAAGEIIQRPANAIKEMMENCLDAKSTNIQITVKEGGLKLILIQDNGTGIRKDDMEIVCERFTTSKLQSFEDLSSIATYGFRGEALASISHVAHVTITTKTADAKCAYRANYCDGKLKSPPKPCAGNQGTLISVEDLFYNVSTRRKALKSPSEEYSRIVEVVSRYAIHNSGKSFSVKKQGEMVADVKTLPNASVLDNIRVVFGVAVSRELIEVECEDQKFAFKVKGYISNANYSVKKCILILFINHRLVESSALKKAIETVYTAYLPKNTHPFLYLSLEIAPQNIDVNVHPTKHEVHFLHEDSIIESIQKHIESKLLGSNSSRTYFTQTLLPGLSASASVAKASSSSADSQERVYAHQMVRTDSKAQKLDAFLQPSASSSSTAAQRKTEKTSSTSTAVQDLVELDDAELLTAADVEPCGGKDPQTDAQPPGDEAPPRKRPHVEEVKEDLTAASLPRRRIVKLTSIKELRDQIELQTHKGLQELLQNHSFVGSVSPQWTLVQHQTKLYLLNTTKLSQELFYQILVYDFGNFGVLRLSNPAPLYDLAMLALDSEESGWTEEDGPKEGLAQYIVDFLKQKAEMLEEYFSLEIDAEGNLTGLPMLLDNYTPAMEGLPMFILRLATEVNWDKEKECFREFSVECSHFYSIRKSYTLEADADEPQDAEMSWQWKVEHVLFKALRSLFSPAKHLSEDGSVLQIASLPDLYKVFERC.
Protein Refseq: The length of the protein is 769 amino acids long. The sequence is show below: MSLRIKALDASVVNKIAAGEIIISPVNALKEMMENSIDANATMIDILVKEGGIKVLQITDNGSGINKADLPILCERFTTSKLQKFEDLSQIQTYGFRGEALASISHVARVTVTTKVKEDRCAWRVSYAEGKMLESPKPVAGKDGTTILVEDLFFNIPSRLRALRSHNDEYSKILDVVGRYAIHSKDIGFSCKKFGDSNYSLSVKPSYTVQDRIRTVFNKSVASNLITFHISKVEDLNLESVDGKVCNLNFISKKSISPIFFINNRLVTCDLLRRALNSVYSNYLPKGNRPFIYLGIVIDPAAVDVNVHPTKREVRFLSQDEIIEKIANQLHAELSAIDTSRTFKASSISTNKPESLIPFNDTIESDRNRKSLRQAQVVENSYTTANSQLRKAKRQENKLVRIDASQAKITSFLSSSQQFNFEGSSTKRQLSEPKVTNVSHSQEAEKLTLNESEQPRDANTINDNDLKDQPKKKQKLGDYKVPSIADDEKNALPISKDGYIRVPKERVNVNLTSIKKLREKVDDSIHRELTDIFANLNYVGVVDEERRLAAIQHDLKLFLIDYGSVCYELFYQIGLTDFANFGKINLQSTNVSDDIVLYNLLSEFDELNDDASKEKIISKIWDMSSMLNEYYSIELVNDGLDNDLKSVKLKSLPLLLKGYIPSLVKLPFFIYRLGKEVDWEDEQECLDGILREIALLYIPDMVPKVDTSDASLSEDEKAQFINRKEHISSLLEHVLFPCIKRRFLAPRHILKDVVEIANLPDLYKVFERC.
Protein Refseq: The length of the protein is 758 amino acids long. The sequence is show below: MGLIQRLPQDVVNRMAAGEVLARPCNAIKELVENSLDAGATEIMVNMQNGGLKLLQVSDNGKGIEREDFALVCERFATSKLQKFEDLMHMKTYGFRGEALASLSHVAKVNIVSKRADAKCAYQANFLDGKMTADTKPAAGKNGTCITATDLFYNLPTRRNKMTTHGEEAKMVNDTLLRFAIHRPDVSFALRQNQAGDFRTKGDGNFRDVVCNLLGRDVADTILPLSLNSTRLKFTFTGHISKPIASATAAIAQNRKTSRSFFSVFINGRSVRCDILKHPIDEVLGARQLHAQFCALHLQIDETRIDVNVHPTKNSVIFLEKEEIIEEIRAYFEKVIGEIFGFEALDVEKPEEEQPDIENLVMIPMSQSLKSIEAIRKPDTKPEFKSSPSAWKSDKKRVDYMEVRTDAKERKIDEFVTRGGAVGPTTSNDDIFGGSGILKRARTEDSTGGEKEPEDLNTDFDDVSMVSLVSTADGRRLNESQDLGEDDDVDFEYGKTHREFHFESIEVLRKEIIANSSQSLREMFKTSTFVGSINVKQVLIQFGTSLYHLDFSTVLREFFYQISVFSFGNYGSYRLDEEPPAIIEILELLGELSTREPNYAAFEVFANVENRFAAEKLLAEHADLLHDYFAIKLDQLENGRLHITEIPSLVHYFVPQLEKLPFLIATLVLNVDYDDEQNTFRTICRAIGDLFTLDTNFITLDKKISAFSATPWKTLIKEVLMPLVKRKFIPPEHFKQAGVIRQLADSHDLYKVFERCGT.
Protein Refseq: The length of the protein is 756 amino acids long. The sequence is show below: MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKGPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEIVGRYSIHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTASLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVPEDKTDISSGRARQQDEEMLELPSPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINERGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC.
Protein Refseq: The length of the protein is 756 amino acids long. The sequence is show below: MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSIHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVTAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINERGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC.
Protein Refseq: The length of the protein is 758 amino acids long. The sequence is show below: MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVVVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNITTRRKALKNPSEEYGKILEVVGRYSIHNSGISFSVKKQGETVADVRTLPSASTVDNIRSIFGNAVSRELIEIGCEDKTLAFRMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSGDKLYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVPEDKTDISSGGARQQDEEMLELPAPAEMAAKNQSLEGDTTKATSEMSEKRGPTSRPGNPRKRHREDSDVDMVEDDSRKDMTAACTPRRRIINLTSVLSLQEEINERGHEILREMLHDHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGSLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFKSLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC.
Protein Refseq: The length of the protein is 233 amino acids long. The sequence is show below: MLHNHSFVGCVNPQWALAQHQTKLYLLNTTRLSEELFYQILVYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLVGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYVSAESTLSGQQSEVPGSTANPWKWTVEHVIYKAFRSHLLPPKHFTEDGNILQLANLPDLYKVFERC.
Protein Refseq: The length of the protein is 757 amino acids long. The sequence is show below: MSQVPGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVVVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLAHISTYGFRGEALASISHVAHVAITTKTADGKCAYRAHYSDGKLKAPPKPCAGNQGTQITVEDLFYNISTRRKALKNPSEEYGKILEVVGRYSIHNSGISFSVKKQGETVADVRTLPNATTVDNIRSIFGNAVSRELIEVECEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEDSILERVQQHIESRLLGSNASRTYFTQTLLPGLTGPSGEAVKSAADVTPSSTGSGDKVYAYQMVRTDCREQKLDAFLQPASKSLSSQPQAIVPEDRTDAFGSEARQQDEEMLELPAPSEVAAKHQSLEEDTAERTSDLSEKRGPPSSPGNPRKRHRESSDVEMVEDANRKEMTAACIPRRRIINLTSVLTLQEEINERGHETLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLVGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEAPGSTPNPWKWTVEHVVYKAFRSYLLPPKCFTEDGNILQLANLPDLYKVFERC.
Protein Refseq: The length of the protein is 750 amino acids long. The sequence is show below: MAGVIRRLEETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVTVKDGGMKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLSNISTYGFRGEALASVSHVAHVTITTKTADGKCAYRASYADGKLKAPPKPCAGNQGTQISVEDLFYNVSTRRKALKSPSEEHARIVEVVSRYAIHNSGIGFSVKKQGETMADVRTLSNATTVDNIRTVFGNAVSRELIGVGCEEDKLAFKMKGYVTNANYSMKKCIFLLFINARLVESTALKKAIETVYAAYLPKNTHPFLYLSLDIAPQNVDVNVHPTKHEVHFLHEDSIIERVQQHIESKLLGSNSSRMYFTQTLLPGHSVCASGFTKPLPASSTSQKSSEKVYAHQMVRTDSREQKLDAFLQPLNRQQLSFSGCQTPENAEGQKHNRVPSEDTKVAEPSDLEILDVLEATANSESYVLKQKKTDDSPNNIEQPRKRPRRVSDVEMLEDVGSVKTLTAASTPRRRIINLTSILSLQKEIEECGHTSLQDMLLNHSFVGCVNPQWALAQFQTKLYLLNTTKLSQELFYQILIYDFGNFGVMKLSEPAPLYDLAMLALDNKESGWTEEDGPKEGLAEYIVQFLKKKTEMLADYYSLEIDQEGNLIGLPLLLDNYIPPMEGLPLFILRLATEVNWDDEKECFASFSKECSNFYSIRKQYILDESSNNADNKSLTGSSSWRWTTEHILYKAFRTHLLPPKPFTEDGSILQIANLPDLYKVFERC.
Protein Refseq: The length of the protein is 730 amino acids long. The sequence is show below: MEDEAIPVPIPKEPPKIQRLEECVVNRIAAGEVIQRPVSAVKELIENSLDADSTSISVVVKDGGLKLIQVSDDGHGIRYEDLPILCERYTTSKLSKFEDLQSIRSMGFRGEALASMTYVGHVTVTTITMGQLHGYRATYRDGLMVDEPKACAAVKGTQIMIENLFYNMAARRKTLQNSADDYPKIVDIISRFGIHHTHVSFSCRKHGAGRADVHTIATSSRLDAIRSVYGASVARDLMNIEVSDTGPLISVFKMDGFISNSNYIAKKTTMVLFINDRLIDCGALKRAIEIVYTATLPKASKPFIYMSIILPPEHVDVNIHPTKREVSFLNQEFVIEKIQSVVGSKLRSSNESRTFQEQTMDLSSSGPMGQDSTKESSPSGIKSQKVPHKMVRTDTLDPSGRLHAYMQMKPPGNSERGPCFSSVRSSIRQRRNPSDTADLTSIQELVNEIDNDCHPGLLDIVRNCTYTGMADEIFALLQHNTHLYLVNVINLSKELMYQQVLRRFAHFNAIQLSEPASLPELVMLALKEEGSDPEGNESKELRGKIAEIEYRTAQAKGWNARRSILVFIIDSNGNMSSLPVYWDQYTPDMGPHPRNLLLWFRKILNWGRTKKFGFQDNWLVVLRKIFLPCIPPLLPKSLRGWLEILQKRELSSGSEVTSIDNIENDTTEAEFDEELRLEAENAWAQREWSIQHVLFPSLRLFFKPPTSMVTNGTFVQVASLEKLYRIFERC.
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Purity
> 90% was determined by SDS-PAGE
Purification
Purified with Protein A or G affinity chromatography
Cellular Localization
Nucleus; Other locations
Application Information
Application
WB, ELISA
Application Notes
ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user.
Target
Introduction
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
Product Overview
Mouse Anti-D. melanogaster Mlh1 Antibody is a mouse antibody against Mlh1. It can be used for Mlh1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
The length of the protein is 664 amino acids long. The sequence is show below: MAEYLQPGVIRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQVQVKAGGLKLLQIQDNGTGIRREDLAIVCERFTTSKLTRFEDLSQIATFGFRGEALASISHVAHLSIQTKTAKEKCGYKATYADGKLQGQPKPCAGNQGTIICIEDLFYNMPQRRQALRSPAEEFQRLSEVLARYAVHNPRVGFTLRKQGDAQPALRTPVASSRSENIRIIYGAAISKELLEFSHRDEVYKFEAECLITQVNYSAKKCQMLLFINQRLVESTALRTSVDSIYATYLPRGHHPFVYMSLTLPPQNLDVNVHPTKHEVHFLYQEEIVDSIKQQVEARLLGSNATRTFYKQLRLPGAPDLDETQLADKTQRIYPKEMVRTDSTEQKLDKFLAPLVKSDSGVSSSSSQEASRLPEESFRVTAAKKSREVRLSSVLDMRKRVERQCSVQLRSTLKNLVYVGCVDERRALFQHETRLYMCNTRSFSEELFYQRMIYEFQNCSEITISPPLPLKELLILSLESEAAGWTPEDGDKAELADGAADILLKKAPIMREYFGLRISEDGMLESLPSLLHQHRPCVAHLPVYLLRLATEVDWEQETRCFETFCRETARFYAQLDWREGATAGFSRWTMEHVLFPAFKKYLLPPPRIKDQIYELTNLPTLYKVFERC.
