Mouse Anti-D. melanogaster Nsmce1 Antibody (CBMOAB-25813FYA)
Cat: CBMOAB-25813FYA
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Fruit fly (Drosophila melanogaster) |
| Clone | MO25813FYA |
| Specificity | This antibody binds to fruit fly Nsmce1. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Nucleus; Other locations |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair. MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. |
| Product Overview | Mouse Anti-D. melanogaster Nsmce1 Antibody is a mouse antibody against Nsmce1. It can be used for Nsmce1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Non-structural maintenance of chromosomes element 1 homolog; Non-SMC element 1 homolog |
| UniProt ID | Q9VMA0 |
| Protein Refseq | The length of the protein is 235 amino acids long. The sequence is show below: MELVKRGFLRACKNHSYLSFELIDDILAPLCANHKTTKPGSKEAIRALVAEINDTISDLGQLLVFIKYPVKAEEYLVYAKTDATPDSVANTGLTAEECQYFSKLLDKIASEEDCHIAWNDAYNDIVLQASSKPLKKSRMQELLQKWIQMGYFMEVTDRIYLGPRSLVELSFYLSSNHADNIKNCTLCKCLVLWDIRCGSCNIQYHRGCIQTYLQRRDICPSCGNLWTTPIRRSIG. |
See other products for " NSMCE1 "
| MO-AB-16971R | Mouse Anti-Cattle NSMCE1 Antibody (MO-AB-16971R) |
| CBMOAB-53041FYA | Mouse Anti-Rhesus NSMCE1 Antibody (CBMOAB-53041FYA) |
| MO-AB-22144W | Mouse Anti-Chimpanzee NSMCE1 Antibody (MO-AB-22144W) |
| CBMOAB-90114FYA | Mouse Anti-Zebrafish nsmce1 Antibody (CBMOAB-90114FYA) |
| MO-AB-37888W | Mouse Anti-Goat NSMCE1 Antibody (MO-AB-37888W) |
| MO-AB-60372W | Mouse Anti-Marmoset NSMCE1 Antibody (MO-AB-60372W) |
For Research Use Only | Not For Clinical Use.
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