Mouse Anti-Dog UMOD Antibody (MO-AB-33932W)


Cat: MO-AB-33932W
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityDog (Canis lupus familiaris)
CloneMO33932W
SpecificityThis antibody binds to Dog UMOD.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationOther locations; Extracellular region or secreted; Plasma membrane; Cytoskeleton

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThe protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.
Product OverviewMouse Anti-Dog UMOD Antibody is a mouse antibody against UMOD. It can be used for UMOD detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesUromodulin; UMOD
UniProt IDF1PH06
Protein RefseqThe length of the protein is 643 amino acids long.
The sequence is show below: MGQLSSLTSVWMVVVVTSWVIIAANIDTVEARSCSECHSNATCMEDGMVTTCSCLVGFTGNGFECVDLDECAIPGAHNCSEGSSCMNTLGSYLCTCPDGFRLTPGLGCIDVDECSEPGLSRCHALATCINNKGNYSCVCPAGYRGDGQHCECSPGSCGPGLDCVPVGDALVCADPCQEHRILDEYWRSTEYGAGYTCDVGLNGWYRFTGPGGVRLAETCVPVLHCNTAAPMWLNGTHPTRDQGIVNRTACAHWRGHCCLWDASIQVKACAGGYYVYNLTETPECYLAYCTDPTSVLGTCEECSVEEDCKSHDGMWSCQCKQDFNVTDLSLLDRRLECRPNDIKVSLSKCQLKSLGFEKVFMYLRDSQCSGFNERGDRDWVSVVTPARDGPCGTVMMRNETHATYSNTLYLADEIIIRDRNIKINFECSYPLDMKVSLETSLQPIVSSLNISVGGTGMFTVRMALFQTPDYTQPYQGSSVTLTTEAFLYVGTMLDGGDLSRFALLMTNCYATPSSNATDPLKYFIIQDRCPRTTDSTIQVVENGESPQGRFSVQMFRFAGNYDLVYLHCEVYLCDIINEKCKPTCSGTRFRSGGIIDQSRVLNLGPITRKNVQAVVSRAASSSLGFLKVCLPLLLSATLTLMFQ.
For Research Use Only | Not For Clinical Use.
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