Mouse Anti-Frog cfi Antibody (MO-AB-02358H)
Cat: MO-AB-02358H
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Frog (Xenopus laevis) |
| Clone | MO02358C |
| Specificity | This antibody binds to Frog cfi. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. |
| Product Overview | This product is a mouse antibody against cfi. It can be used for cfi detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Factor I C3b/C4b inactivator; Serine protease; cfi; factor I |
| UniProt ID | Q03711 |
| Protein Refseq | The length of the protein is 613 amino acids long. The sequence is show below: MNKLCCVLILFCHFYVNTFSSAVSGAGDARPNTCEFNALSCHKVFCAPWQRCVAGVCRCKLPYQCPKNATTEVCTDGKRKLQSYCQLKSVECSNPLNSKYRFSSEAPCTETFTLTQNGEPGKGIIKVKLPTFEQELFLCGKQWSNREANVVCRQLGSTKGADASASDKVFSLVTEKPPEHCIQATCRGLENSLAECALRKLPMQDNQVAKVTCYTENKDCGFGEFTCSNGKCIPSELACDSKNDCGDLSDELCCKSCNAGFHCRSDTCIPEQYRCNGELDCIGGEDESNCTVEQEQKSEKQEEVEQKQTSEKQEEDLVQESKATQVEEKAKIVNYDIDAERRLLMKSLPELSCGVPPQTAALTLTRKKRVIGGTNAVKNQFPWQVAIKDGTAVNCGGIYIGGCWVLTAAHCVRSNQPQRYLIMLELLDRLSYDKDLDSFPVKSVIVHELYNPNTYENDIALLEVKNIYNNPKCMQADNNMVPACVPWSPFQFKAGDTCTVSGWGREKGMSRVFHLKWGHINLMDNCTRVYKERFLDKMECARTYDGSIDACKGDSGGPLVCYDVNKVAYVWGIVSWGENCGVPGYPGVYTKVANYFEWIAHQVGRSLMSKYNV. |
See other products for " Cfi "
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For Research Use Only | Not For Clinical Use.
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