Anti-H2A Antibody (Cat MO-MMB-0687), Rabbit IgG
Cat: MO-MMB-0687
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product List
- Specifications
- Application Information
- Target
Specifications
| Host species | Rabbit (Oryctolagus cuniculus) |
| Species Reactivity | Budding Yeast, Fission Yeast |
| Immunogen | Recombinant yeast histone H2A. |
| Format | Liquid or Lyophilized |
| Buffer | 30% Glycerol |
| Regulatory Status | For Research Use Only |
| Shipping | Gel Pack |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purification | Protein A purified |
Application Information
| Application | ChIP, IP, WB |
| Application Notes | WB: 1:2000-1:5000 The optimal dilution should be determined by the end user. |
Target
| Introduction | Histone H2A is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points; it is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; they play a major role in regulating gene expression. |
| Alternative Names | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
See other products for " H2A "
| MOFAB-015W | Rabbit Anti-H2A Antibody (MOFAB-015W) |
| MO-AB-02751Y | Mouse Anti-H2A Antibody (MO-AB-02751Y) |
| MO-AB-11571Y | Mouse Anti-H2A Antibody (MO-AB-11571Y) |
For Research Use Only | Not For Clinical Use.
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