Rabbit Anti-ITGB1 Antibody (AA 21-250)


Cat: MO-NAB-00430W
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Specifications

Host speciesRabbit (Oryctolagus cuniculus)
Species ReactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Zebrafish (Danio rerio)
CloneNW0355
SpecificityThis antibody is binds to Human ITGB1 and has cross reactivity with Mouse, Rat, Zebrafish.
ImmunogenHuman integrin β1/CD29 aa 21-250 recombinant protein.
EpitopeThe epitope is in the AA 21-250 of ITGB1.
FormatLiquid or Lyophilized
BufferTBS, pH7.4, 1% BSA, 40% Glycerol.
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurificationProtein A purified
Cellular LocalizationCell Membrane; Cell projection; Cleavage furrow

Application Information

ApplicationWB, IHC, IHC-P
Application NotesWestern Blot: 1:500-1:5000
Immunohistochemistry-Paraffin: 1:50-1:200

Target

IntroductionIntegrin β-1 (ITGB1), also known as CD29, is a cell surface receptor encoded by the ITGB1 gene. The integrin binds to integrin α1 and integrin α2 to form an integrin complex that functions as a collagen receptor. It also forms a dimer with integrin α3, thereby forming integrin receptors for netrin 1 and reelin. These and other integrin β1 complexes have historically been called very late activation (VLA) antigens.Integrin β1 is expressed as at least four different isoforms. In cardiac and skeletal muscles, integrin β-1D isoforms are specifically expressed and located in the ribs, where they contribute to the lateral force transmission from the Z disk to the extracellular matrix. Abnormal levels of integrin β-1D were found in limb-girdle muscular atrophy and polyneuropathy.
Product OverviewThis product is a Rabbit antibody against the AA 21-250 of the ITGB1. It can be used for ITGB1 detection in Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.
Alternative NamesITGB1; CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA; VLAB; integrin subunit beta 1
Gene ID3688(Human); 16412(Mouse)
UniProt IDP05556(Human); P09055(Mouse)
For Research Use Only | Not For Clinical Use.
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