Mouse Anti-NPC1 Antibody (CBMOAB-37463FYC)


Cat: CBMOAB-37463FYC
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Lot Number

  • Product List
  • Specifications
  • Application Information
  • Target
Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
CBMOAB-37463FYC Monoclonal A. thaliana (Arabidopsis thaliana), Cat (Felis catus), Cattle (Bos taurus), Chimpanzee (Pan troglodytes), Dog (Canis lupus familiaris), Hamsters (Cricetinae), Marmoset, Pig (Sus scrofa), Rabbit (Oryctolagus cuniculus), Rhesus (Macaca mulatta), Zebrafish (Danio rerio) WB, ELISA MO37463FC 100 µg
CBMOAB-52879FYA Monoclonal Rhesus (Macaca mulatta) WB, ELISA MO52879FYA 100 µg
CBMOAB-89707FYA Monoclonal Zebrafish (Danio rerio) WB, ELISA MO89707FYA 100 µg
MO-AB-09206W Monoclonal Cat (Felis catus) WB, ELISA MO09206W 100 µg
MO-AB-18745W Monoclonal Chimpanzee (Pan troglodytes) WB, ELISA MO18745W 100 µg
MO-AB-32200W Monoclonal Dog (Canis lupus familiaris) WB, ELISA MO32200W 100 µg
MO-AB-43314W Monoclonal Hamsters (Cricetinae) WB, ELISA MO43314W 100 µg
MO-AB-60245W Monoclonal Marmoset WB, ELISA MO60245W 100 µg
MO-AB-16871R Monoclonal Cattle (Bos taurus) WB, ELISA MO16871R 100 µg
MO-AB-27810R Monoclonal Pig (Sus scrofa) WB, ELISA MO27810R 100 µg
MO-AB-08976Y Monoclonal Rabbit (Oryctolagus cuniculus) WB, ELISA MO08976Y 100 µg

Specifications

Host speciesMouse (Mus musculus)
Species ReactivityA. thaliana (Arabidopsis thaliana), Cat (Felis catus), Cattle (Bos taurus), Chimpanzee (Pan troglodytes), Dog (Canis lupus familiaris), Hamsters (Cricetinae), Marmoset, Pig (Sus scrofa), Rabbit (Oryctolagus cuniculus), Rhesus (Macaca mulatta), Zebrafish (Danio rerio)
CloneMO37463FC
SpecificityThis antibody binds to Arabidopsis NPC1.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationGolgi apparatus; Extracellular region or secreted

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThis gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.
Product OverviewMouse Anti-Arabidopsis NPC1 Antibody is a mouse antibody against NPC1. It can be used for NPC1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesNPC Intracellular Cholesterol Transporter 1; Niemann-Pick Disease, Type C1; Truncated Niemann-Pick C1; Niemann-Pick C1 Protein; SLC65A1; NPC
UniProt IDQ8L7Y9
Protein RefseqThe length of the protein is 533 amino acids long. The sequence is show below: MAFRRVLTTVILFCYLLISSQSIEFKNSQKPHKIQGPIKTIVVVVMENRSFDHILGWLKSTRPEIDGLTGKESNPLNVSDPNSKKIFVSDDAVFVDMDPGHSFQAIREQIFGSNDTSGDPKMNGFAQQSESMEPGMAKNVMSGFKPEVLPVYTELANEFGVFDRWFASVPTSTQPNRFYVHSATSHGCSSNVKKDLVKGFPQKTIFDSLDENGLSFGIYYQNIPATFFFKSLRRLKHLVKFHSYALKFKLDAKLGKLPNYSVVEQRYFDIDLFPANDDHPSHDVAAGQRFVKEVYETLRSSPQWKEMALLITYDEHGGFYDHVPTPVKGVPNPDGIIGPDPFYFGFDRLGVRVPTFLISPWIEKGTVIHEPEGPTPHSQFEHSSIPATVKKLFNLKSHFLTKRDAWAGTFEKYFRIRDSPRQDCPEKLPEVKLSLRPWGAKEDSKLSEFQVELIQLASQLVGDHLLNSYPDIGKNMTVSEGNKYAEDAVQKFLEAGMAALEAGADENTIVTMRPSLTTRTSPSEGTNKYIGSY.
For Research Use Only | Not For Clinical Use.
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