Mouse Anti-O. anatinus TERT Antibody (MO-AB-06938Y)
Cat: MO-AB-06938Y
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | O. anatinus (Ornithorhynchus anatinus) |
| Clone | MO06938Y |
| Specificity | This antibody binds to O. anatinus TERT. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Other locations; Nucleus |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. |
| Product Overview | This product is a mouse antibody against TERT. It can be used for TERT detection in Western Blot and Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Telomerase reverse transcriptase; TERT |
| UniProt ID | F2YSU1 |
| Protein Refseq | The length of the protein is 1296 amino acids long. The sequence is show below: MASAAPFFAVHAVLRARYAAVLPLPDFVGGLPGAPRGLLPLGDPGDPEIFQTFLAQCVVCLPRGARPLPDPLTFRQLSSQKEIVARIVQRICEKGKKNVLAFGYTLLDENSRSEPVVFTSNVCNYLPNISTESVRTSILWEMLFSRVGDDVIMYLLEHCALFMLVPPNCSYQICGQPIYELPPTDSSPPRPSSPRFFRQRASNRRRDVLSEYVREKIRLHGRRGEQSDRKRRKRRVGERESGAGGRRETRLPSRRTNPGGRERDRPVTDGPRKRPDPGLAPRAAKRYLEKDERGTSGKRRKGAVLAGRDGGPDPGSPSPATPTREVRPEAPGSEASEASRGLLQMQSVPGGRRDREDSRIPSDPPFPERVRGNLVRPGPRVPKTRGLEAPSQPGSTGSAPPGWSSPARSPREEESPRSGAGEQTPGRGPPGSVPESSRAACRPGVFIDRKRLLYSSRDLKERLPRSFPLNRLRGDPAGGRGLVEAIFLAGSLREGRRDPAGRRLGRKKRRLPGRYWRMRHVFRELLQNHGRCPYGVLLRKSCPVRVGAAEPAAGTGPPGGPAGVSLRSAGRAGGRRTASPAGGSPEGSRRAGAVSPTASPGAGWGVHDLLRQHSSSWRVYGFVRECLLRVVPAELWGSSHNKCRFLRNVKAFLALGKFDKFSLRELRWKMRVSDCAWLRSGRGDHSVPASEHRFREEILAKFLHWLMRAYVVELLRAFFYVTETMFQKNLLFFYRKCVWNRLQAIGIRNHLAKVQLQAISEKEIKENLSKKYVPVVSKLRFIPKSNGLRPIVNADTIAGAKLFPKESRDKKVQYFNTQLKNLFSVLNYERTLHPHLLGASMFGIDDIYKAWRQFVLRVLTSKDKERRFYFVKADVTGAYDTIPHDKLVEVISRILKPEDETVYCIQRYAVIQKTAKGSVRKTFRRHVSTLKDFPPSMKQFVSHLQETTSLQNAVVVQQSSSLNETSTSLFAFFRHMIQHNILKIRNRYYVQRRGIPQGSILSTLLCSLCYGDMENRLFPGIQQDGVLLRLIDDFLLVTPHLAQAKLFLRTLAKGIPEYGCFINPRKTVVNFHVDEDTVGCSHFTQLPAGCLFPWCGLLLDTRTLEVYCDYSTYSRTSIRASLSLCQSTSAGRSLRRKLLTVLKLKCHGLFLDVQVNSLRTVCINIYKIFLLQAYRFHACVLRLPFNQRVRKNPEFFLTVIADTASCCYSMVRARNAGVTLGAREASGPFPSEAAQWLCYQAFLTKLANHKVVYKCLLGPLKRSKQQLLRRLPGPTMLMLEAATDPMLCQDFKTILD. |
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For Research Use Only | Not For Clinical Use.
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