Mouse Anti-Rhesus A2M (clone MO34738FYA) Antibody (CBMOAB-34738FYA)


Cat: CBMOAB-34738FYA
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityRhesus (Macaca mulatta)
CloneMO34738FYA
SpecificityThis antibody binds to Rhesus A2M.
FormatLyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationExtracellular region or secreted

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionThe protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
Product OverviewMouse Anti-Rhesus A2M (clone MO34738FYA) Antibody (CBMOAB-34738FYA) is a mouse antibody against A2M. It can be used for A2M detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesAlpha-2-macroglobulin; A2M
UniProt IDH9YYI2
Protein RefseqThe length of the protein is 1474 amino acids long.
The sequence is show below: MGRNTLLHPSLVLLLLVLLPTDVSVSGKPQYMVLVPSLLHTETPEKGCVLLSYLNETVTVSASLESVRGNRSLFTDLEAENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPTQEFKKRTTVMVKNEESLVFVQTDKSIYKPEQTVKFRVVSLDENFHPVNELIPLVYIQDPKGNRIAQWQSFQLEGGLKQLSFPLSSEPFQGSYKVVVQKKSGRRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTVSICRKYSDASDCFGEDSKAFCEKFSGQLNSHGCFYQQVKTKVFQLKRKEYEMKLHTEAKIQEEGTVVELTGKKSSEITRTITKLSFVKVDSNFRQGIPFFGQVRLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSINTTNVMGTTLTVRVKHKDRSPCYGYQWVSEEHEEAHHTAYLVFSPSKSFVHLEPLPHELPCGQTQTVQAHYILNGGALQGLKKLSFYYLIMARGGIVRTGTHGLLVKQEHMKGHFSISIPVKSDIAPVARLLIYAVLPTGDVIGDSAKYEVENCLDNKVDLSFRPSQSLPASHAHLQVTAAPQSLCALRAVDQSVLLMKPDAELSASSVYNLLPVKDLTGFPEPLNDQDDEDCVNRHNVYINGITYTPVSNTNEKDIYSFLQDMSLKAFTNSKIRKPKICPQLQQYEMHGPEGLRVGYYDSDVMGRGQARKLQLEEPHTETVRKYFPETWIWDLVVVNSSGVAEVGVTVPDTITDWKAGAFCLSQDSGLGISPTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAFLAVPVEKEQEPHCICANGRQTVSWAITPKSLGNVNFTVSAEALESQELCGTEVASVPQYGKKDTIIKPLLVEPEGLEKETTFNSLLCPSGGEVSEELSLKLPPNVVEESARASVSVLGDILGSAMQNIQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIESKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQKQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLPVTHPVVRNALFCLESAWKTTQEGAHGSHVYTKALLAYAFALAGNQEKRKEVLESLNEEAVKKDNSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNVVKWITKQQNSQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIQSSGTFSNKFQVDNSNRLLLQRVSLPELPGEYSMKVTGEGCVYLQTSLKYNILPEKEEFPFALGVQTLPATCDEPKARTSFQISLSVSYTGSRSASNMAIVDVKMVSGFIPLKPTVKTLERSNHVSRTEVSNNHVLIYLDKVSNQTLSLFFTVLQDVPVRDLKPAIVKVYDYYETDEFAIAEYNAPCSKDLGNA.
For Research Use Only | Not For Clinical Use.

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