Mouse Anti-Sheep ATAT1 Antibody (MO-AB-14273Y)
Cat: MO-AB-14273Y
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Sheep (Ovis aries) |
| Clone | MO14273Y |
| Specificity | This antibody binds to Sheep ATAT1. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Other locations; Cytosol; Cytoskeleton; Golgi apparatus |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. |
| Product Overview | This product is a mouse antibody against ATAT1. It can be used for ATAT1 detection in Western Blot and Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Alpha-tubulin N-acetyltransferase 1; Alpha-TAT; Alpha-TAT1; TAT; EC 2.3.1.108; Acetyltransferase mec-17 homolog; ATAT1; MEC17 |
| UniProt ID | W5PS62 |
| Protein Refseq | The length of the protein is 421 amino acids long. The sequence is show below: MEFPFDVDALLPERITVLDQHLRPPARRPGTTTPARVDLQQQIMTIVDELGKASAKAQHLPAPITSASRMQSNRHVMYILKDTSARPAGKGAIVGFLKVGYKKLFVLDDREAHNEVEPLCILDFYIHESLQRHGHGRELFQHMLQKERVEPHQLAIDRPSQKLLKFLNKHYNLETTVPQVNNFVIFEGFFAHQHRPPATSLRATRHSRAAALDPMPAAPARKLPPKRAEGDIKPYSSSDREFLKVAVEPPWPLNRAPRRATPPAHPPPRSSSLGNSPERGPLRPFVPEQELLRSLRLCPPHPTARLLLATDPGGSPAQRRRTSGTPPGLVAQSCSYSRHGRLNSSCPNTGNQELKQGEQETENRCAIEEQVLSQHGSGEEPMHTVPPQAQVPPAQAWTMGGDMFNARFIRNLHERRSTRPW. |
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For Research Use Only | Not For Clinical Use.
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