Mouse Anti-tax Antibody (MOFAB-163W)


Cat: MOFAB-163W
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Specifications

Host speciesMouse
Species ReactivityHtlv
CloneW1A3
SpecificityThis antibody reacts with HTLV-1 Tax expressed in transiently transfected cells.
ImmunogenRecombinant full-length HTLV-Tax protein.
FormatLiquid or Lyophilized
BufferLyophilized
Regulatory StatusFor Research Use Only
ShippingGel Pack
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurificationProtein A

Application Information

ApplicationWB, IHC, ELISA
Application NotesELISA: 0.1-1.0ug/ml
IB: 2-10ug/ml
IHC: 2-20ug/ml
The optimal dilution should be determined by the end user.

Target

IntroductionThe nonstructural regulatory Tax protein is a unique feature of delta retroviruses, a subgroup of retroviruses that confer long-lasting infection in mammalian lymphocytes. These proteins are essential for efficient viral replication, and they stimulate the proliferation of host lymphocytes. Tax has been shown to be carcinogenic as it transforms and immortalizes rodent fibroblasts and human T lymphocytes. Tax also stimulates cell growth by directly binding cyclin-dependent kinase pore enzymes and/or inactivating tumor suppressors (eg, p53, DLG). In addition, Tax silences cellular checkpoints, thereby preventing DNA structural damage and chromosome missegregation, thereby favoring the expression of mutant phenotypes in cells.
Product OverviewThe tax antibody is used as Infectious Disease Antibodies.
Alternative NamesHTLV-1 Tax; tax; p40; HTLV-1 Tax
Gene ID1491938
UniProt IDP14079
For Research Use Only | Not For Clinical Use.
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