AibGenesis™ Mouse Anti-SRB2 Antibody (CBMOAB-04192CR)


Cat: CBMOAB-04192CR

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Lot Number

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Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
CBMOAB-04192CR Monoclonal Yeast, C. elegans (Caenorhabditis elegans) WB, ELISA MO04192CR 100 µg
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CBMOAB-10289HCB Monoclonal C. elegans (Caenorhabditis elegans) WB, ELISA MO10289HB 100 µg
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityYeast, C. elegans (Caenorhabditis elegans)
CloneMO04192CR
SpecificityThis antibody binds to Yeast SRB2.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationNucleus

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionComponent of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. (From uniprot, under CC BY 4.0)
Product OverviewMouse Anti-Yeast SRB2 Antibody is a mouse antibody against SRB2. It can be used for SRB2 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesMediator of RNA polymerase II transcription subunit 20; Hyper-recombination suppressor protein 2; Mediator complex subunit 20; Suppressor of RNA polymerase B 2; SRB2; HRS2 MED20; YHR041C
UniProt IDP34162
Protein RefseqThe length of the protein is 210 amino acids long. The sequence is show below: MGKSAVIFVERATPATLTELKDALSNSILSVRDPWSIDFRTYRCSIKNLPADVSKLMYSITFHHHGRQTVLIKDNSAMVTTAAAADIPPALVFNGSSTGVPESIDTILSSKLSNIWMQRQLIKGDAGETLILDGLTVRLVNLFSSTGFKGLLIELQADEAGEFETKIAGIEGHLAEIRAKEYKTSSDSLGPDTSNEICDLAYQYVRALEL.
For Research Use Only | Not For Clinical Use.
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