AibGenesis™ Mouse Anti-no66 Antibody (CBMOAB-89542FYA)


Cat: CBMOAB-89542FYA

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Lot Number

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  • Specifications
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Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
CBMOAB-89542FYA Monoclonal Zebrafish (Danio rerio), Fruit fly (Drosophila melanogaster) WB, ELISA MO89542FYA 100 µg
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MO-AB-02879W Monoclonal Fruit fly (Drosophila melanogaster) WB, ELISA MO02879W 100 µg
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityZebrafish (Danio rerio), Fruit fly (Drosophila melanogaster)
CloneMO89542FYA
SpecificityThis antibody binds to Zebrafish no66.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationNucleus

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionOxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. (From uniprot, under CC BY 4.0)
Product OverviewMouse Anti-Zebrafish no66 Antibody is a mouse antibody against no66. It can be used for no66 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesBifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; EC 1.14.11.-; EC 1.14.11.27; Histone lysine demethylase NO66; no6
UniProt IDA3KP59
Protein RefseqThe length of the protein is 544 amino acids long.
The sequence is show below: MERKHMSALSIYQSLSGGKTPQAEDKAPPAKKVKRKENGVRPSKKATKKKGTKPLKSSVRSSSSEKEKHEGERDCREMNGKRFDNVALDILLTDLAKVNNSRDRANRLFQWLIHPVQDKSFFRDNWEKKPILIQRQNADYYKGLFSTAEFDRILRNDDVQYGVNLDVTSYTNGKRETHNPPGRALPYTVWDFYESGCSIRMLNPQAFSSTVWQVLSVLQEKFGSMAGANVYLTPPGTQGFAPHFDDIEAFVVQLEGRKHWRVYNPRCEDEVLSLVSSPNFSQDEIGEPVMDVVLEAGDLLYFPRGFVHQGDCLPDAHSLHITISSYQRNSWGDLMLKLMPAALEVAMEEDVEFRKGLPLDYLQYMGVQNSEKEDPRRDRFMAHIQGLMKKLVSFAPVDAAVDQKAKDFLHDCLPPLLTAEEKAGSVYGAPARWGDSEALDVAVELKSQTRIKLVRAGAARLCSDGDTVHLYYTTENSRVYHKEASKSFEMKTEHIDAMEFLIHSYPKFVSVASLPCETAEAKMSLAELLFEKGLIFTAEPLTAQ.
For Research Use Only | Not For Clinical Use.
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