FAS-associated death domain protein
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Mouse Anti-fadD Antibody (CBMOAB-0735YC) (CAT#: CBMOAB-0735YC)
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- Host species: Mouse
- Species Reactivity: E. coli (Escherichia coli ), A. aegpti (Aedes aegpti), Cattle (Bos taurus), Chimpanzee (Pan troglodytes), Frog (Xenopus laevis), Fruit fly (Drosophila melanogaster), Marmoset, O. mykiss (Oncorhynchus mykiss), Pig (Sus scrofa), Rat (Rattus norvegicus), Zebrafish (Danio rerio)
- Application: WB, ELISA
- Protein: Long-chain-fatty-acid--CoA ligase
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, None, PE, PerCP
- Alternative Names: Long-chain-fatty-acid--CoA ligase, EC 6.2.1.3, Long-chain acyl-CoA synthetase, Acyl-CoA synthetase, fadD, oldD, b1805 JW1794
For Research Use Only | Not For Clinical Use.
