TATA-Box Binding Protein
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]
Mouse Anti-TBP Antibody (MO-AB-21324R) (CAT#: MO-AB-21324R)
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- Host species: Mouse
- Species Reactivity: Cattle (Bos taurus), Chicken (Gallus gallus), Dog (Canis lupus familiaris), Frog (Xenopus laevis), Fruit fly (Drosophila melanogaster), Human (Homo sapiens), S. cerevisiae (Saccharomyces cerevisiae), Malaria parasite, Medaka (Oryzias latipes), Pig (Sus scrofa), Rhesus (Macaca mulatta), S. cerevisiae, Sheep (Ovis aries), Zebrafish (Danio rerio)
- Application: WB, ELISA
- Protein: TATA-box-binding protein
- Size: 0.5mg, 1mg, 200µg
- Conjugate: AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: TATA-box-binding protein, TATA sequence-binding protein, TATA-binding factor, TATA-box factor, Transcription initiation factor TFIID TBP subunit, TBP
Mouse Anti-TBP Antibody, IgG2b kappa (MOFY-0922-FY58) (CAT#: MOFY-0922-FY58)
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- Host species: Mouse
- Species Reactivity: S. cerevisiae, Chicken (Gallus gallus), Dog (Canis lupus familiaris), Frog (Xenopus laevis), Fruit fly (Drosophila melanogaster), Human (Homo sapiens), S. cerevisiae (Saccharomyces cerevisiae), Malaria parasite, Medaka (Oryzias latipes), Pig (Sus scrofa), Rhesus (Macaca mulatta), Sheep (Ovis aries), Zebrafish (Danio rerio)
- Application: WB, IP, IF, ELISA
- Protein: TATA-Box Binding Protein
- Size: 200µg
- Alternative Names: TATA-Box Binding Protein, Transcription Initiation Factor TFIID TBP Subunit, TATA Sequence-Binding Protein, TATA-Box Factor, GTF2D1, TFIID, TATA-Box Binding Protein N-Terminal Domain
