Tight junction protein ZO-1 isoform b
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms.
Mouse Anti-TJP1 Antibody (MO-AB-66226W) (CAT#: MO-AB-66226W)
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- Host species: Mouse
- Species Reactivity: Marmoset, Chimpanzee (Pan troglodytes), Dog (Canis lupus familiaris), Rhesus (Macaca mulatta)
- Application: WB, ELISA
- Protein: Submitted name: Tight junction protein ZO-1 isoform a
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Tight junction protein ZO-1 isoform a, TJP1
For Research Use Only | Not For Clinical Use.
