Cat: MO-DKB-01420W
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- Product Details
Specifications
| Host species | Rabbit (Oryctolagus cuniculus) |
| Species Reactivity | Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Bovine (Bos taurus), Rabbit (Oryctolagus cuniculus), Rhesus (Macaca mulatta) |
| Immunogen | A recombinant protein containing the sequence in the central region of human aconitase 1. |
| Epitope | The epitope is in the Center of ACO1. |
| Format | Liquid |
| Buffer | 0.1M Tris, pH 7, 0.1M Glycine, 20% Glycerol |
| Storage | Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
| Purity | Affinity purified |
| Cellular Localization | Cytoplasm |
Application Information
| Application | WB, IF |
| Application Notes | Western Blot 1:500-1:3000 Immunocytochemistry/Immunofluorescence 1:100-1:1000 |
Target
| Introduction | The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014] |
| Product Overview | This product is a Rabbit antibody against the Center of the ACO1. It can be used for ACO1 detection in Western Blot, Immunofluorescence. |
| Alternative Names | Aconitase 1; Iron-Responsive Element-Binding Protein 1; Aconitate Hydratase, Cytoplasmic; Ferritin Repressor Protein; Iron Regulatory Protein 1; Cytosplasmic Aconitase; Aconitase 1, Soluble; Citrate Hydro-Lyase; Soluble Aconitase; EC 4.2.1.3; IRE-BP 1; |
| Gene ID | 48 |
| UniProt ID | P21399 |
See other products for " ACO1 "
| MO-AB-07058Y | Mouse Anti-Rabbit ACO1 Antibody (MO-AB-07058Y) |
| MO-AB-38810W | Mouse Anti-Grape ACO1 Antibody (MO-AB-38810W) |
| CBMOAB-1532FYC | Mouse Anti-Arabidopsis ACO1 Antibody (CBMOAB-1532FYC) |
| MO-AB-34092H | Mouse Anti-Tomato ACO1 Antibody (MO-AB-34092H) |
| MO-AB-28222W | Mouse Anti-Cucumber aco1 Antibody (MO-AB-28222W) |
| MO-DKB-0020RA | Rabbit Anti-ACO1 Antibody (MO-DKB-0020RA) |
| CBMOAB-18474FYB | Mouse Anti-Rice ACO1 Antibody (CBMOAB-18474FYB) |
| CBMOAB-1534FYC | Mouse Anti-Arabidopsis ACO1 Antibody (CBMOAB-1534FYC) |
| CBMOAB-1533FYC | Mouse Anti-Arabidopsis ACO1 Antibody (CBMOAB-1533FYC) |
| CBMOAB-64658FYA | Mouse Anti-Zebrafish aco1 Antibody (CBMOAB-64658FYA) |
For Research Use Only | Not For Clinical Use.