Mouse Anti-AKT1 Antibody


Cat: MO-NAB-00364W
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Rabbit (Oryctolagus cuniculus), Chicken (Gallus gallus), Zebrafish (Danio rerio)
CloneNW0290
SpecificityThis antibody is binds to Human AKT1 and has cross reactivity with Mouse, Rat, Rabbit, Chicken, Zebrafish.
ImmunogenThis AKT1 phosphorylated Ser473 antibody was raised against a synthetic peptide containing phosphorylated serine at amino acid residue 473 of human AKT1.
FormatLiquid or Lyophilized
BufferPBS
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
PurificationProtein G purified
Cellular Localizationp Ser473

Application Information

ApplicationWB, IHC, IHC-P
Application NotesImmunohistochemistry: 1:200-1:250
Immunohistochemistry-Paraffin: 1:200-1:250

Target

IntroductionThe serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
Product OverviewThis product is a Mouse antibody against the AKT1. It can be used for AKT1 detection in Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.
Alternative NamesAKT Serine/Threonine Kinase 1; V-Akt Murine Thymoma Viral Oncogene Homolog 1; Protein Kinase B Alpha; Proto-Oncogene C-Akt; RAC-PK-Alpha; EC 2.7.11.1; PKB Alpha; PKB; RAC; V-Akt Murine Thymoma Viral Oncogene-Like Protein 1; RAC-Alpha Serine/Threonine-Protein Kinase
Gene ID207 (Human); 11651 (Mouse); 24185 (Rat)
UniProt IDP31749 (Human); P31750 (Mouse); P47196 (Rat)
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For Research Use Only | Not For Clinical Use.
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