AibGenesis™ Mouse Anti-C. elegans elt-2 Antibody (Full length)
Cat: MO-NAB-00517W
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
| Size: | |
| Conjugate: | |
| Inquiry |
- Specifications
- Application Information
- Target
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | C. elegans (Caenorhabditis elegans) |
| Clone | NW0439 |
| Specificity | This antibody is binds to C. elegans elt-2. |
| Immunogen | Recombinant His-tagged ELT-2-fusion protein. |
| Epitope | The epitope is in the Full length of elt-2 |
| Format | Liquid or Lyophilized |
| Buffer | Supernatant |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Application Information
| Application | ChIP, IF, WB |
Target
| Introduction | Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' (PubMed:7782329, PubMed:15733671, PubMed:18003741, PubMed:18024960, PubMed:18448117, PubMed:26700680, PubMed:26016853). Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1 and lev-11, and itself (PubMed:9659934, PubMed:10518545, PubMed:15733671, PubMed:18448117, PubMed:19111532, PubMed:26700680). Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine (PubMed:20807527). Regulates intestinal gene expression in response to hypoxia to promote longevity (PubMed:25284791). Regulates tissue specific gene expression at basal levels and in response to bacterial infection in the intestine to control innate immununity (PubMed:16968778, PubMed:21168435, PubMed:25340560, PubMed:26016853). Plays a role in the induction of metal-responsive genes, activating gene expression from zinc-activated promoters and iron-dependent promoters and enhancers (PubMed:18024960, PubMed:22194696, PubMed:25552416). May regulate the expression of genes that control sensitivity to oxidative stress, in a mab-3-dependent manner, and osmotic stress, in conjunction with the GATA region-binding transcription factor elt-3 (PubMed:17901115, PubMed:20498281, PubMed:20126308). May play a role in sphingolipid signaling by regulating the expression of the sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735). May act with the Notch signaling pathway to promote endodermal gene expression (PubMed:18003741). Has a protective role in response to infection by Gram-negative bacteria such as S.enterica, E.coli, P.aeruginosa and B.pseudomallei, Gram-positive bacterium E.faecalis and fungal pathogen C.neoformans (PubMed:16968778, PubMed:17183709, PubMed:21168435, PubMed:23980181, PubMed:30265660). An association with the 26S proteasome regulatory subunit rpt-6, in part, controls gene expression in response to infection by P.aeruginosa (PubMed:30265660). Regulates gene expression during the recovery phase following a bacterial infection (PubMed:25340560, PubMed:30265660). May act with p38-activated transcription factors to control p38 gene induction in response to bacterial infection (PubMed:22967128, PubMed:26016853). Controls lysosome formation in the intestine by controlling lysosomal gene expression (PubMed:26828939). (From uniprot, under CC BY 4.0) |
| Product Overview | This product is a Mouse antibody against the Full length of the elt-2. It can be used for elt-2 detection in Chromatin Immunoprecipitation, Immunofluorescence, Western Blot. |
| Alternative Names | Transcription factor elt-2; elt-2 |
| Gene ID | 181250 |
| UniProt ID | Q10655 |
For Research Use Only | Not For Clinical Use.
Online Inquiry