Connect with Us at the Upcoming Events

Creative Biolabs is excited to greet you at the upcoming international conferences. Meet our team at the 13th Annual World ADC San Diego and the 13th Annual World Multispecific Summit in September, the 10th Annual Immuno-Oncology Summit in October, and the Antibody Engineering & Therapeutics (US) 2022 in December for expert consultation on your drug discovery projects. Shoot an email to arrange an in-person meeting!

Mouse Anti-C. elegans ITR1 Antibody (CBMOAB-05494HCB)


Cat: CBMOAB-05494HCB
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

  • Product Details

Specifications

Host speciesMouse (Mus musculus)
Species ReactivityC. elegans (Caenorhabditis elegans)
CloneMO05494HB
SpecificityThis antibody binds to C. elegans ITR1.
FormatLyophilized
StorageStore at 4°C: short-term (1-2 weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationPlasma Membrane; Endoplasmic reticulum; Other locations

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionReceptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis (PubMed:10499793, PubMed:10610772, PubMed:15194811, PubMed:16186564, PubMed:23671426). Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position (PubMed:10610772). Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity (PubMed:10610772). Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyngeal pumping (PubMed:10499793, PubMed:11553721, PubMed:12062062, PubMed:11950942, PubMed:15013747, PubMed:15133127, PubMed:16186564, PubMed:21191812). Affects normal hermaphrodite and male fertility as a participant in intracellular signaling by acting downstream of let-23/lin-3 which regulates ovulation, spermathecal valve dilation and male mating behavior (PubMed:9491893, PubMed:15194811, PubMed:16267094, PubMed:15958491). Important for early embryonic development; controls epidermal cell migration and may also regulate filopodial protrusive activity during epithelial morphogenesis (PubMed:11950942, PubMed:15498499, PubMed:18369461). Component of inositol trisphosphate (IP3)-mediated downstream signaling pathways that controls amphid sensory neuronal (ASH)-mediated response to nose touch and benzaldehyde but not other ASH-mediated responses (PubMed:19730689).
Product OverviewMouse Anti-C. elegans ITR1 (clone MO05494HB) Antibody (CBMOAB-05494HCB) is a mouse antibody against ITR1. It can be used for ITR1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesInositol 1,4,5-trisphosphate receptor itr-1; IP3 receptor; IP3R; InsP3R; LET-23 fertility effector 1; itr-1
UniProt IDQ9Y0A1
Protein RefseqThe length of the protein is 2892 amino acids long. The sequence is show below: MNPSYGRVRKKVSIISIPEFVPEHYEYENETTASGGASGGGSTRIEFDFDDFEEQIMRKSSMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGQQLRQLLLQRYFGHHNNHHPPLDRQQSKIGEVIEAVKEKKEETWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPSEKDDNDDEKKVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTFFVVLIVIVLNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR.
For Research Use Only | Not For Clinical Use.

Online Inquiry