Mouse Anti-C. elegans PGL1 Antibody (CBMOAB-08332HCB)

Cat: CBMOAB-08332HCB

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Size:
Conjugate:
	Inquiry

Specifications
Application Information
Target

Specifications

Host species	Mouse (Mus musculus)
Species Reactivity	C. elegans (Caenorhabditis elegans)
Clone	MO08332HB
Specificity	This antibody binds to C. elegans PGL1.
Format	Liquid or Lyophilized
Storage	Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use
Purity	> 90% was determined by SDS-PAGE
Purification	Purified with Protein A or G affinity chromatography

Application Information

Application	WB, ELISA
Application Notes	ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

Introduction	Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3''-guanylic residue and the 5''-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2'',3''-cyclic phosphate intermediate (PubMed:26787882). Together with the P-granule component pgl-3, is involved in the formation of P-granules (PubMed:21402787, PubMed:24746798). Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules (PubMed:21402787). In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis during normal oogenesis and development of the two gonadal arms (PubMed:26598553). This may in part be through regulating the localization of sir-2.1 which is involved in germ cell apoptosis (PubMed:26598553). May protect somatic cells from excessive apoptosis during normal development (PubMed:27650246). Essential role in male and female postembryonic germline development; maternally provided protein maintains a population of proliferating germ cells and zygotic expression is required for correct oogenesis (PubMed:9741628, PubMed:15238518, PubMed:24746798).
Product Overview	Mouse Anti-C. elegans PGL1 Antibody is a mouse antibody against PGL1. It can be used for PGL1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative Names	Protein PGL-1, isoform b; pgl-1
UniProt ID	Q304E5
Protein Refseq	The length of the protein is 771 amino acids long. The sequence is show below: MEVSDLRVSKRTTRRERGSCNFDLVPIFFSVFLLFWFHPFHMEANKREIVDFGGLRSYFFPNLAHYITKNDEELFNNTSQANKLAAFVLGASKDAPGDEDILEMILPNDANAAVIAAGMDVCLLLGDKFRPKFDAAAEKLSGLGHAHDLVSVIDDDKKLGMLARKAKLKKTEDAKILQALLKVIAIDDAAEKFVELTELVSQLDLDFDVYVLTKILGLISEETSDEVDIIRDNVVNAFDSCKPLLKQLMLDGPKSEPADPFISLLMDPLEESVGKVVNHIAQLFEEASKNEGDESLVLRSQLGYQLFFLIVRSLADGKREVSKKILSGIPTSVRAEVFPGLQRSVYKSAVFLGNHIIQVLLGSKKSFEDWDVVGVAKDLESAWKRRAIAELIKKFQVSILEQCFDKPVPLIPQSPLNNDAVIDNVNKALQFALWLTEFYGSENETEALGELRFLDSTSKNLLVDSFKKFVQGINSKTHVTRIVESLEKCCLSDTPSGRKSNVQPSTSQQQDSAYTKEEMTTVHNTYSVNTKAQVLNGLSDTNSSGLLVDSKDSLSLQEISCDEVDSSTLLSSSRNIGEGVTVKAVDPVPEKVNDAQQQQTVNEIEMASDANQDTSSSASPEVAPSFSTDGWDSPTKSVALPPGMQQIDEEETTVADKDSTPQPQARAETAWGSGDATPMPLPAPTNQYKVSGFGEAKVAKGFGQFAPTSSAYGGGGGRGGYGGGDRGGRGGYGGDRGGRGGYGGGDRGGRGGYGGDRGRGGYGGRGGRGGF.

For Research Use Only | Not For Clinical Use.

Online Inquiry