AibGenesis™ Mouse Anti-C. elegans tir-1 Antibody (CBMOAB-59207FYC)
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Lot Number
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- Specifications
- Application Information
- Target
- Relate Reference Data
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | C. elegans (Caenorhabditis elegans) |
| Clone | MO59207FYC |
| Specificity | This antibody binds to C. elegans tir-1. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Product Overview | Mouse Anti-C. elegans tir-1 (clone MO59207FYC) Antibody (CBMOAB-59207FYC) is a mouse antibody against tir-1. It can be used for tir-1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Toll and interleukin 1 receptor domain protein isoform c; tir-1 |
| UniProt ID | Q5I9W0 |
| Protein Refseq | The length of the protein is 984 amino acids long. The sequence is show below: MLPNRKPPRPSPSFQSLNNNNQRFPLRRSLKIAQAHSLPTVPSEDAKDDDLITPELSTDFDFREIQHRYLMALQNEQDGETTSTDDAFFELDDDDDLSSPSVPGSPVDPPSISVPLPPKSAPPCPTQPAPLTNGDLYPTILSNGTPIPNGRITPALSTVSVSLIHEARLQQSLSTPCNGSEEEMHNGQVRKESEYRRFKSEGSTAGASLPAAEKTHMDELSPVDQRSTSGTARFLIQQDSVVNPSTKMSNTEQVAMMHTLKTKLSKYQAMMDKAFEEIAKVEDANIIEGCTIVRKLMRKVWNTPKVSADLANALCDYLRDRDYFDKLIKMFISPNTAACDQVRMECGKVLEECTSSANLEYIVNKSYTKKIMIVAMKLNKTPDQQRLSLSLIGNLFKHSNAVSLSLIETDVIDHIILTFKRAPECPDILRHAALALANILLYTCFEGKKKIIQKKIPEWLFFLASQADDVTRYYACIAVCTIVSVKEFEPLVRKSDTMKLVEPFLQVHDPATFARDYHKYAQGNTKEWLERLLPMLQPSRRREARSVAAFHFTLEATIKKEQNKLDVFQEIGAIQALKEVASSPDEVAAKFASEALTVIGEEVPYKLAQQVPGWTCADVQYWVKKIGFEEYVEKFAKQMVDGDLLLQLTENDLKHDVGMISGLHRKRFLRELQTLKVAADYSSVDESNLDNFLMGLSPELSVYTYQMLTNGVNRSLLSSLTDEMMQNACGITNPIHRLKLTQAFETAKHPDDVEVAMLSKQIDVFISYRRSTGNQLASLIKVLLQLRGYRVFIDVDKLYAGKFDSSLLKNIQAAKHFILVLTPNSLDRLLNDDNCEDWVHKELKCAFEHQKNIIPIFDTAFEFPTKEDQIPNDIRMITKYNGVKWVHDYQDACMAKVVRFITGELNRTTPTTKEMPSISRKTTQQRWQTTNTVSRTGPSRSIGGPRMEPPTPTFFSVTPTGSQERATSTRRKIQPSASTTSDRN. |
Relate Reference Data
IF
Figure 1 Multimerization of TIR-1/SARM1 and its intrinsic NAD+ glycohydrolase activity are required for activation of the p38 PMK-1 innate immune pathway during pathogen infection. Images of animals expressing TIR-1::wrmScarlet in the indicated conditions. All tir-1::wrmScarlet animals were treated with glo-3(RNAi) to deplete autofluorescent gut granules. Representative images for each condition are displayed. Red fluorescent channel images display both TIR-1::wrmScarlet fluorescence and autofluorescent signal, while the green fluorescent channel images only display signals from autofluorescent gut granules. TIR-1::wrmScarlet puncta are indicated by arrowheads and autofluorescent gut granules by asterisks. Scale bar equals 20 μm (2 μm for the inset enlarged images).
IF
Figure 2 Sterol stress activates the C. elegans p38 immune pathway through the multimerization and NAD + glycohydrolase activity of TIR-1/SARM1. Images of tir-1::wrmScarlet and nhr-8(hd117);tir-1::wrmScarlet animals as described in exposed to either 0.1% Tergitol or tir-1(RNAi).