Mouse Anti-Cattle CIAPIN1 Antibody (MO-AB-10243R)
Cat: MO-AB-10243R
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- Product Details
Specifications
Host species | Mouse (Mus musculus) |
Species Reactivity | Cattle (Bos taurus) |
Clone | MO10243R |
Specificity | This antibody binds to Cattle CIAPIN1. |
Format | Liquid or Lyophilized |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 90% was determined by SDS-PAGE |
Purification | Purified with Protein A or G affinity chromatography |
Cellular Localization | Mitochondrion; Nucleus; Other locations |
Application Information
Application | WB, ELISA |
Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
Introduction | CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 or CASP families. Expression of CIAPIN1 is dependent on growth factor stimulation. Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells. |
Product Overview | Mouse Anti-Cattle CIAPIN1 Antibody is a mouse antibody against CIAPIN1. It can be used for CIAPIN1 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
Alternative Names | Anamorsin; Cytokine-induced apoptosis inhibitor 1; Fe-S cluster assembly protein DRE2 homolog; CIAPIN1 |
UniProt ID | Q5EAC7 |
Protein Refseq | The length of the protein is 310 amino acids long. The sequence is show below: MADFGISAGQFVAVIWDKSSPVEALKDLVDKLQALTGDEGRVSVENINQLLQSAHKESSFDIVLSGIIPGSTTLHSADILAEMARILRPGGCLFLKEPVETAVVNNSKVKTASKLCSALTLSGLVEVKELQRESLSPEEIQSVREHLGYHSDSLLSLQITGKKPNFEVGSSSQLKLSIAKKSSGKPAVDPAAAKLWTLSANDMEDESVDLIDSDELLDAEDLKKPDPASLRAPSCGEGKKRKACKNCTCGLAEEL. |
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For Research Use Only | Not For Clinical Use.
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