Mouse Anti-Cattle NUDT16 Antibody (MO-AB-17026R)
Cat: MO-AB-17026R
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Cattle (Bos taurus) |
| Clone | MO17026R |
| Specificity | This antibody binds to Cattle NUDT16. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Nucleus; Other locations |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms (PubMed:20385596, PubMed:26121039). The order of activity with different substrates is IDP> dIDP>> GDP = dGDP> XDP = ITP = dITP (PubMed:20385596). Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions (PubMed:20385596). |
| Product Overview | This product is a mouse antibody against NUDT16. It can be used for NUDT16 detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Nudix-type motif 16; U8 snoRNA-decapping enzyme; NUDT16 |
| UniProt ID | Q1JPK7 |
| Protein Refseq | The length of the protein is 201 amino acids long. The sequence is show below: MRRLELSEALHLGPGWRHACHALLYAPDPGLLFGRIPLRYAVLMQMRFDGRLGFPGGFVDLRDGSLEDGLNRELGEELGEAAGAFRVERADYRSSHAGSRPRVVAHFYTKLLTLEQLTAVEMGAPRARDHGLEVGPAQDPTPPPPAPEGLSQLYPRVVGVWVINYSQPGLPAKILLSLLFTGLCIVFLKLSHPNHSSATTL. |
See other products for " NUDT16 "
| MO-AB-12026W | Mouse Anti-Chimpanzee NUDT16 Antibody (MO-AB-12026W) |
| MO-AB-27605H | Mouse Anti-Rat Nudt16 Antibody (MO-AB-27605H) |
| MO-AB-16377Y | Mouse Anti-Sheep NUDT16 Antibody (MO-AB-16377Y) |
| CBMOAB-37700FYC | Mouse Anti-Arabidopsis NUDT16 Antibody (CBMOAB-37700FYC) |
For Research Use Only | Not For Clinical Use.
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