U8 snoRNA-decapping enzyme
RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms (PubMed:20385596, PubMed:26121039). The order of activity with different substrates is IDP> dIDP>> GDP = dGDP> XDP = ITP = dITP (PubMed:20385596). Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions (PubMed:20385596).
Mouse Anti-Arabidopsis NUDT16 Antibody (CBMOAB-37700FYC) (CAT#: CBMOAB-37700FYC)
-
- Host species: Mouse
- Species Reactivity: A. thaliana (Arabidopsis thaliana)
- Application: WB, ELISA
- Protein: Nudix hydrolase 16, mitochondrial
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, None, PE, PerCP
- Alternative Names: Nudix Hydrolase 16, Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 16, Nucleoside Diphosphate-Linked Moiety X Motif 16, Inosine Diphosphate Phosphatase, U8 SnoRNA-Binding Protein H29K, M7GpppN-MRNA Hydrolase, IDP Phosphatase, Nudix Motif 16
Mouse Anti-Chimpanzee NUDT16 Antibody (MO-AB-12026W) (CAT#: MO-AB-12026W)
-
- Host species: Mouse
- Species Reactivity: Chimpanzee (Pan troglodytes)
- Application: WB, ELISA
- Protein: Submitted name: Nudix (Nucleoside diphosphate linked moiety X)-type motif 16
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Nudix (Nucleoside diphosphate linked moiety X)-type motif 16, NUDT16
Mouse Anti-Sheep NUDT16 Antibody (MO-AB-16377Y) (CAT#: MO-AB-16377Y)
-
- Host species: Mouse
- Species Reactivity: Sheep (Ovis aries)
- Application: WB, ELISA
- Protein: Submitted name: U8 snoRNA-decapping enzyme
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: U8 snoRNA-decapping enzyme, NUDT16
Mouse Anti-Cattle NUDT16 Antibody (MO-AB-17026R) (CAT#: MO-AB-17026R)
-
- Host species: Mouse
- Species Reactivity: Cattle (Bos taurus)
- Application: WB, ELISA
- Protein: Submitted name: Nudix-type motif 16
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Nudix-type motif 16, U8 snoRNA-decapping enzyme, NUDT16
Mouse Anti-Rat Nudt16 Antibody (MO-AB-27605H) (CAT#: MO-AB-27605H)
-
- Host species: Mouse
- Species Reactivity: Rat (Rattus norvegicus)
- Application: WB, ELISA
- Protein: Submitted name: Nudix (Nucleoside diphosphate linked moiety X)-type motif 16 (Predicted), isoform CRA_a
- Size: 0.5mg, 1mg, 200µg
- Conjugate: Alexa Fluor 350, AP, APC, Biotin, Consult us more, Cy3, Cy5, Cy5.5, Cy7, FITC, HRP, NONE, PE, PerCP
- Alternative Names: Nudix (Nucleoside diphosphate linked moiety X)-type motif 16, isoform CRA_a, Protein Nudt16, Nudt16
