Mouse Anti-NUDT16 Antibody (MO-AB-17026R)


Cat: MO-AB-17026R
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Lot Number

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Sub Cat Clonality Species Reactivity Application Clone Conjugate Size  
MO-AB-17026R Monoclonal Cattle (Bos taurus), Chimpanzee (Pan troglodytes), Rat (Rattus norvegicus), Sheep (Ovis aries) WB, ELISA MO17026R 100 µg
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MO-AB-12026W Monoclonal Chimpanzee (Pan troglodytes) WB, ELISA MO12026W 100 µg
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MO-AB-27605H Monoclonal Rat (Rattus norvegicus) WB, ELISA MO27605C 100 µg
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MO-AB-16377Y Monoclonal Sheep (Ovis aries) WB, ELISA MO16377Y 100 µg
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityCattle (Bos taurus), Chimpanzee (Pan troglodytes), Rat (Rattus norvegicus), Sheep (Ovis aries)
CloneMO17026R
SpecificityThis antibody binds to Cattle NUDT16.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationNucleus; Other locations

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionRNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms (PubMed:20385596, PubMed:26121039). The order of activity with different substrates is IDP> dIDP>> GDP = dGDP> XDP = ITP = dITP (PubMed:20385596). Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions (PubMed:20385596).
Product OverviewThis product is a mouse antibody against NUDT16. It can be used for NUDT16 detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative NamesNudix-type motif 16; U8 snoRNA-decapping enzyme; NUDT16
UniProt IDQ1JPK7
Protein RefseqThe length of the protein is 201 amino acids long.
The sequence is show below: MRRLELSEALHLGPGWRHACHALLYAPDPGLLFGRIPLRYAVLMQMRFDGRLGFPGGFVDLRDGSLEDGLNRELGEELGEAAGAFRVERADYRSSHAGSRPRVVAHFYTKLLTLEQLTAVEMGAPRARDHGLEVGPAQDPTPPPPAPEGLSQLYPRVVGVWVINYSQPGLPAKILLSLLFTGLCIVFLKLSHPNHSSATTL.
See other products for " NUDT16 "
CBMOAB-37700FYCMouse Anti-NUDT16 Antibody (CBMOAB-37700FYC)
For Research Use Only | Not For Clinical Use.
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