Mouse Anti-Chicken HMGCR Antibody (MO-AB-02299Y)
Cat: MO-AB-02299Y
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- Product Details
Specifications
Host species | Mouse (Mus musculus) |
Species Reactivity | Chicken (Gallus gallus) |
Clone | MO02299Y |
Specificity | This antibody binds to Chicken HMGCR. |
Format | Liquid or Lyophilized |
Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
Purity | > 90% was determined by SDS-PAGE |
Purification | Purified with Protein A or G affinity chromatography |
Application Information
Application | WB, ELISA |
Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
Introduction | HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Product Overview | This product is a mouse antibody against HMGCR. It can be used for HMGCR detection in Western Blot and Enzyme-Linked Immunosorbent Assay. |
Alternative Names | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMGCR |
UniProt ID | V9IPL6 |
Protein Refseq | The length of the protein is 28 amino acids long. The sequence is show below: GSAMAGSIGGYNAHAANIVTAIYIACGQ. |
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For Research Use Only | Not For Clinical Use.
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