Mouse Anti-Guinea pig HMGCR Antibody (MO-AB-41807W)


Cat: MO-AB-41807W
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityGuinea pig (Cavia porcellus)
CloneMO41807W
SpecificityThis antibody binds to Guinea pig HMGCR.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationPeroxisome; Other locations; Endoplasmic reticulum

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionHMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Product OverviewMouse Anti-Guinea pig HMGCR Antibody is a mouse antibody against HMGCR. It can be used for HMGCR detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative Names3-hydroxy-3-methylglutaryl coenzyme A reductase; HMG-CoA reductase; EC 1.1.1.34; HMGCR
UniProt IDH0V2S7
Protein RefseqThe length of the protein is888 amino acids long.
The sequence is show below: MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGDNKVCGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTAEHPKVSLGLDENAPKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPGVAQKKVPDSCCRREPVLVRNNQKLQSVEEETGINQERKVEVIKPLVADTDTSNRATFVLGTSCLPDPPSDLVTQEPEIQLPREPRPAEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLAEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLSLDGKEFQVPMATTEGCLVASTNRGCRAISLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETPEGFAVIKEAFDSTSRFARLQKLHTSMAGRNLYIRFQSKTGDAMGMNMISKGTEKALSKLHEYFPEMQVLAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSLEIGTVGGGTNLLPQQACLQMLGVQGACVDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGTCTKKAS.
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For Research Use Only | Not For Clinical Use.
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