Mouse Anti-Chicken WNT5A Antibody (MO-AB-04790Y)
Cat: MO-AB-04790Y
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product Details
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Chicken (Gallus gallus) |
| Clone | MO04790Y |
| Specificity | This antibody binds to Chicken WNT5A. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Extracellular region or secreted; Other locations |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur (PubMed:16754689). Inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells (By similarity). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle (By similarity). Inhibits type II collagen expression in chondrocytes (PubMed:16754689). |
| Product Overview | This product is a mouse antibody against WNT5A. It can be used for WNT5A detection in Western Blot and Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Protein Wnt; WNT5A |
| UniProt ID | Q9YGX6 |
| Protein Refseq | The length of the protein is 385 amino acids long. The sequence is show below: MEKSTAVLIQGGALGTLGSTMASQYLVVALAIFSSCTQVVIEASSWWSLGMNPMNPMNPVQMSEVYIIGAQPLCSQLAGLSQGQKKLCQLYQDHMQFIGEGAKTGIKECQYQFRHRRWNCSTVDNNSVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELSSCGCSRAARPKDLPRDWLWGGCGDNIEYGYRFAKEFVDARERERVYQRGSYESARIMMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNSRGKLVQMNSRFNAPTIHDLIYIDPSPDYCMRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQRERCHCKFHWCCYVKCKLCTEIVDQFVCK. |
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For Research Use Only | Not For Clinical Use.
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