Mouse Anti-D. melanogaster Alas Antibody (CBMOAB-00803FYA)


Cat: CBMOAB-00803FYA
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  • Specifications
  • Application Information
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Specifications

Host speciesMouse (Mus musculus)
Species ReactivityFruit fly (Drosophila melanogaster)
CloneMO00803FYA
SpecificityThis antibody binds to fruit fly Alas.
FormatLiquid or Lyophilized
StorageStore at 4°C: short-term (1-2weeks)
Store at -20°C: long-term and future use
Purity> 90% was determined by SDS-PAGE
PurificationPurified with Protein A or G affinity chromatography
Cellular LocalizationMitochondrion

Application Information

ApplicationWB, ELISA
Application NotesELISA: 1:1000-1:3000
Other applications are to be developed. The optimal dilution should be determined by the end user.

Target

IntroductionCatalyzes the attachment of L-alanine to tRNA(Ala) in a two-step reaction: L-alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). AlaRS also incorrectly activates the sterically smaller amino acid glycine as well as the sterically larger amino acid L-serine; generates 2-fold more mischarged Gly than Ser (PubMed:28362257). These mischarged amino acids occur because the of inherent physicochemical limitations on discrimination between closely related amino acids (Ala, Gly and Ser) in the charging step.
Product OverviewMouse Anti-D. melanogaster Alas Antibody is a mouse antibody against Alas. It can be used for Alas detection in Western Blot, Enzyme-Linked Immunosorbent Assay.
Alternative Names5-aminolevulinate synthase; EC 2.3.1.37; 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase; Alas
UniProt IDQ8T4G6
Protein RefseqThe length of the protein is 539 amino acids long.
The sequence is show below: MQCPFLNRFTASFIRNYAETLCQSYGSHCPVVGKTLVSGEKKLLLVAASVTRSHSTGANAHANAGGPATANATAPVSAPASADPGKASAKETFPYERFFNEQIMKKKRDHSYRVFKKVNRLAGDGLFPHALEYSERTEKPITVWCSNDYLGMSAHPGVKRAVQDALNRHGSGAGGTRNISGNSLHHERLESKLAELHQKEAALLFTSCFVANDSTLFTLAKLLPGCEIFSDAGNHASMIMGIRNSGVPKHIFRHNDVDHLHQLLKQTDKSVPKIVAFETVHSMTGAICPLEELLDVAHEHGAITFIDEVHAVGLYGDHGAGVGERDGVLHKMDIISGTLGKAFGNIGGYIAGTHNLVDMIRSYAAGFIFTTSLPPTVLCGALEAVNILASEEGRQLRHLHQRNVSYLKSLLKREGFPVEETPSHIIPIKIGDPLKSSQISNVLIEQFGHYLQSINYPTVARGQEKLRLAPTPFHTFEMMNALVTDLKKVWEMVDLSTNVPLSPNACMFCNSESCWHQDTSPDLECGIPNCPRLEISLAA.
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