AibGenesis™ Mouse Anti-FBH1 Antibody (MO-AB-01859Y)
Cat: MO-AB-01859Y
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Product List
- Specifications
- Application Information
- Target
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Chicken (Gallus gallus), Marmoset |
| Clone | MO01859Y |
| Specificity | This antibody binds to Chicken FBH1. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Nucleus; Other locations |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17283053). Also promotes cell death and DNA double-strand breakage in response to replication stress: promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. (From uniprot, under CC BY 4.0) |
| Product Overview | This product is a mouse antibody against FBH1. It can be used for FBH1 detection in Western Blot and Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | F-box helicase; FBH1 |
| UniProt ID | A1YKW0 |
| Protein Refseq | The length of the protein is 1012 amino acids long. The sequence is show below: MHLTADDCEALSRSTEGLSSLTQPLNQRRSRGDVNRGLQPTHRTRTQPGAQGRQKNIMDYFKVSQRQQAVAGRTKDISIKEEVLDPFFAEDDESSISSVMETSGDSSSFLEDEYMGNSRKRPLSSTAPGRLQIENDLWGEPEKKAVVVHPEHSQIKQELDDEIEIEPVPDSHYGLLGTRNWEVPQGSIEDLPDEVLRSIFAFLPVTDLYQSLSLVCRRWRIIVGDPWFIPWKKLYHQYLVKEDMALRRVEQVLQDFAITGQHKECILGLIRCVSTIPTSRNVDPSAVLQCLKGHHLFSRAEVCITNKLPHLQSKTGPEYMWAIITAMVLFSDGVRDIQRLMACLQRPCSSLSIVDVTETLYCIATLLYAMREKNINITNRIHYNIFYCLYLMENASVTAPQVVEEETPSSRCRQDFWSSSLSEVKLTHEQQRILNHKIERGQIVKIMAFAGTGKTSTLVKYAEKFADLSFLYVTFNKAVAERGRLVFPRNVTCKTFHSLAFGSVGKLYKEKGKLNFSKLSAYSVSFLIQNREGQSIFIRGKTVSQTLENFFASSDEEICEEHTPIWFKNTHGERKLVTPEEKRINVEEAKEIWRNMKKLDGDVERKYKITCDGYLKLWQLSKPQLSGYDAIFVDEAQDCTPAIVDIVLSQTCGVILVGDPHQQIYSFRGAVNTLYTVPHTHIYYLTQSFRFGPEIAYVGATILDVCKGIRNKTLVGGNQEGDVRGSMEGKITMLSRSNFTVFEDAAKLAGRERQIKIHIIGGLVRFGLSKIYDIWKLSQPADEREKANLVINDSFIKRWEENEGFIGLKDYATRVDDKELEMKIRIVEKFKERIPELVQKIESSHVLQEAMADYLIGTVHQAKGLEFDTVLIADDFVDVPCARDNNQRRPQFIIGMCPEDEWNLLYVAVTRAKKCLLMSQSLEHLLALAGEHFLRVELMGEAVKTGVACSAQQCTQTLQSGIRLVVKKLPLIHSNGSRDMGGYLCYSCVQKRFGSMTPLAFLPALQEEPIVL. |
For Research Use Only | Not For Clinical Use.
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