AibGenesis™ Mouse Anti-FMO Antibody (CBMOAB-60344FYC)
Cat: CBMOAB-60344FYC
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- Product List
- Specifications
- Application Information
- Target
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Rhesus (Macaca mulatta), O. mykiss (Oncorhynchus mykiss) |
| Clone | MO60344FYC |
| Specificity | This antibody binds to Rhesus FMO. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | The flavin-containing monooxygenase (FMO) protein family specializes in the oxidation of xeno-substrates in order to facilitate the excretion of these compounds from living organisms.[1] These enzymes can oxidize a wide array of heteroatoms, particularly soft nucleophiles, such as amines, sulfides, and phosphites. This reaction requires an oxygen, an NADPH cofactor, and an FAD prosthetic group.[2][3][4] FMOs share several structural features, such as a NADPH binding domain, FAD binding domain, and a conserved arginine residue present in the active site. Recently, FMO enzymes have received a great deal of attention from the pharmaceutical industry both as a drug target for various diseases and as a means to metabolize pro-drug compounds into active pharmaceuticals.[5] These monooxygenases are often misclassified because they share activity profiles similar to those of cytochrome P450 (CYP450), which is the major contributor to oxidative xenobiotic metabolism. However, a key difference between the two enzymes lies in how they proceed to oxidize their respective substrates; CYP enzymes make use of an oxygenated heme prosthetic group, while the FMO family utilizes FAD to oxidize its substrates. (From NCBI) |
| Product Overview | Mouse Anti-Rhesus FMO Antibody is a mouse antibody against FMO. It can be used for FMO detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Flavin-containing monooxygenase; EC 1.-.-.-; FMO |
| UniProt ID | F7B240 |
| Protein Refseq | The length of the protein is 286 amino acids long. The sequence is show below: MQDKKKIAVIGAGVSGLGAIKSCFEEGLEPVCSEKNNDIGGLWRYKETPESGRPGIYKSMTCNTSKEMTTFSDYPFPDPYPNYLHNSKMMEYLRMYNRHFHLIKHIQFLSKVCRVRKHPDFSSCGQWDVVVETDGKQTCVFDGIMICSGYYKNITLELETKSSSGKPRSRSRHSGETYKHHDNFVGKTAVVVGIGNSGADVAGEISYIAEQVFLSTRRGAWIWNWVWDNGNPDITVFTCYNTIMEKIFPTFMINKWVENKLNARFNHDNYGLQPQHSWIESIQVIS. |
For Research Use Only | Not For Clinical Use.
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