AibGenesis™ Mouse Anti-Fruit fly CkIalpha Antibody (MO-AB-02363W)
Cat: MO-AB-02363W
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- Specifications
- Application Information
- Target
Specifications
| Host species | Mouse (Mus musculus) |
| Species Reactivity | Fruit fly (Drosophila melanogaster) |
| Clone | MO02363W |
| Specificity | This antibody binds to Fruit fly CkIalpha. |
| Format | Liquid or Lyophilized |
| Storage | Store at 4°C: short-term (1-2weeks) Store at -20°C: long-term and future use |
| Purity | > 90% was determined by SDS-PAGE |
| Purification | Purified with Protein A or G affinity chromatography |
| Cellular Localization | Other locations; Cytosol; Nucleus |
Application Information
| Application | WB, ELISA |
| Application Notes | ELISA: 1:1000-1:3000 Other applications are to be developed. The optimal dilution should be determined by the end user. |
Target
| Introduction | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Negative regulator of wg signaling (PubMed:22095083). Phosphorylates arm directly or indirectly and stimulates its degradation which prevents inappropriate wg signaling (PubMed:11955436, PubMed:11927557, PubMed:22095083). Phosphorylates smo which promotes its accumulation at the cell surface and its signaling activity in response to hh (PubMed:15616566). Together with dco, regulates proteolytic processing of ci by phosphorylating it which promotes its binding to slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin-protein ligase required for ci processing (PubMed:16326393). Inhibits condensin II interphase activity by promoting degradation of the Cap-H2 regulatory subunit and limiting the levels of chromatin-bound Cap-H2 which regulates interphase chromosome organization (PubMed:25723539). (From uniprot, under CC BY 4.0) |
| Product Overview | Mouse Anti-Fruit fly CkIalpha Antibody is a mouse antibody against CkIalpha. It can be used for CkIalpha detection in Western Blot, Enzyme-Linked Immunosorbent Assay. |
| Alternative Names | Casein kinase I isoform alpha; CKI-alpha; DmCK1; EC 2.7.11.1; CkIalpha; CKI |
| UniProt ID | P54367 |
| Protein Refseq | The length of the protein is 337 amino acids long. The sequence is show below: MDKMRILKESRPEIIVGGKYRVIRKIGSGSFGDIYLGMSIQSGEEVAIKMESAHARHPQLLYEAKLYRILSGGVGFPRIRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRLEYIHLKCFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKFRDPHTRHHIVYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVMMYFNRGVLPWQGMKANTKQQKYEKISEKKMSTPIEVLCKGSPAEFSMYLNYCRSLRFEEQPDYMYLRQLFRILFRTLNHQYDYIYDWTMLKQKTHQGQPNPAILLEQLDKDKEKQNGKPLIAD. |
For Research Use Only | Not For Clinical Use.
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